Giel Hendriks
Overview
Explore the profile of Giel Hendriks including associated specialties, affiliations and a list of published articles.
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50
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932
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Recent Articles
11.
Jamalpoor A, Hartvelt S, Dimopoulou M, Zwetsloot T, Brandsma I, Racz P, et al.
Birth Defects Res
. 2022 Mar;
114(19):1210-1228.
PMID: 35289129
Background: Testing for developmental toxicity according to the current regulatory guidelines requires large numbers of animals, making these tests very resource intensive, time-consuming, and ethically debatable. Over the past decades,...
12.
Geijer M, Moelijker N, Zhang G, Derr R, Osterlund T, Hendriks G, et al.
Toxicol Sci
. 2022 Jan;
186(2):288-297.
PMID: 35094094
Aneuploidy is characterized by the presence of an abnormal number of chromosomes and is a common hallmark of cancer. However, exposure to aneugenic compounds does not necessarily lead to cancer....
13.
Derr R, Moelijker N, Hendriks G, Brandsma I
Regul Toxicol Pharmacol
. 2022 Jan;
129:105120.
PMID: 35038485
Cobalt metal and cobalt sulfate are carcinogenic in rodents following inhalation exposure. The pre-carcinogenic effects associated with exposure to these cobalt substances include oxidative stress and genotoxicity. Some, but not...
14.
Cediel-Ulloa A, Isaxon C, Eriksson A, Primetzhofer D, Sortica M, Haag L, et al.
Sci Rep
. 2021 Nov;
11(1):21846.
PMID: 34750422
Welding fumes induce lung toxicity and are carcinogenic to humans but the molecular mechanisms have yet to be clarified. The aim of this study was to evaluate the toxicity of...
15.
Boreiko C, Hendriks G, Derr R, Huppert M, Rossman T
Mutat Res Genet Toxicol Environ Mutagen
. 2021 Apr;
865:503333.
PMID: 33865539
Antimony (Sb) and its compounds are negative in gene mutation assays in bacteria and cultured mammalian cells but positive in some assays for clastogenicity and/or DNA damage. In order to...
16.
Czekala L, Chapman F, Simms L, Rudd K, Sticken E, Wieczorek R, et al.
Mutagenesis
. 2021 Mar;
36(2):129-142.
PMID: 33769537
In vitro (geno)toxicity assessment of electronic vapour products (EVPs), relative to conventional cigarette, currently uses assays, including the micronucleus and Ames tests. Whilst informative on induction of a finite endpoint...
17.
Brandsma I, Moelijker N, Derr R, Hendriks G
Toxicol Sci
. 2020 Jul;
177(1):202-213.
PMID: 32617558
Understanding the mode-of-action (MOA) of genotoxic compounds and differentiating between direct DNA interaction and indirect genotoxicity is crucial for their reliable safety assessment. ToxTracker is a stem cell-based reporter assay...
18.
van der Ven L, Rorije E, Sprong R, Zink D, Derr R, Hendriks G, et al.
Chem Res Toxicol
. 2020 Feb;
33(3):834-848.
PMID: 32041405
The ongoing developments in chemical risk assessment have led to new concepts building on integration of sophisticated nonanimal models for hazard characterization. Here we explore a pragmatic approach for implementing...
19.
McCarrick S, Cappellini F, Kessler A, Moelijker N, Derr R, Hedberg J, et al.
Nanomaterials (Basel)
. 2020 Jan;
10(1).
PMID: 31935871
The increased use of nanoparticles (NPs) requires efficient testing of their potential toxic effects. A promising approach is to use reporter cell lines to quickly assess the activation of cellular...
20.
Sasaki J, Allemang A, Bryce S, Custer L, Dearfield K, Dietz Y, et al.
Environ Mol Mutagen
. 2019 Oct;
61(1):114-134.
PMID: 31603995
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of...