Gianni Colotti
Overview
Explore the profile of Gianni Colotti including associated specialties, affiliations and a list of published articles.
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Articles
83
Citations
1359
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Recent Articles
1.
Frappaolo A, Zaccagnini G, Riparbelli M, Colotti G, Callaini G, Giansanti M
Open Biol
. 2025 Feb;
15(2):240267.
PMID: 39999877
The PACS (phosphofurin acidic cluster sorting protein) proteins are membrane trafficking regulators, required for maintaining cellular homeostasis and preventing disease states. Mutations in human and cause human neurodevelopmental disorders, characterized...
2.
Tito C, Masciarelli S, Colotti G, Fazi F
J Biomed Sci
. 2025 Feb;
32(1):24.
PMID: 39966897
The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem...
3.
Exertier C, Antonelli L, Fiorillo A, Bernardini R, Colotti B, Ilari A, et al.
Cancers (Basel)
. 2024 Aug;
16(16).
PMID: 39199583
SOluble Resistance-related Calcium-binding proteIN (sorcin) earned its name due to its co-amplification with ABCB1 in multidrug-resistant cells. Initially thought to be an accidental consequence of this co-amplification, recent research indicates...
4.
Marrocco F, Falvo E, Mosca L, Tisci G, Arcovito A, Reccagni A, et al.
Cell Death Dis
. 2024 Apr;
15(4):262.
PMID: 38615026
Gliomas are among the most fatal tumors, and the available therapeutic options are very limited. Additionally, the blood-brain barrier (BBB) prevents most drugs from entering the brain. We designed and...
5.
Fracasso G, Falvo E, Tisci G, Sala G, Colotti G, Cingarlini S, et al.
Heliyon
. 2023 Oct;
9(10):e20770.
PMID: 37860543
Background: Cancer is still among the leading causes of death all over the world. Improving chemotherapy and minimizing associated toxicities are major unmet medical needs. Recently, we provided a preliminary...
6.
Mattioli R, Ilari A, Colotti B, Mosca L, Fazi F, Colotti G
Mol Aspects Med
. 2023 Jul;
93:101205.
PMID: 37515939
Anthracyclines have been important and effective treatments against a number of cancers since their discovery. However, their use in therapy has been complicated by severe side effects and toxicity that...
7.
Valentini E, Di Martile M, Brignone M, Di Caprio M, Manni I, Chiappa M, et al.
Cell Death Dis
. 2023 Jul;
14(7):441.
PMID: 37460459
BH3 mimetics, targeting the Bcl-2 family anti-apoptotic proteins, represent a promising therapeutic opportunity in cancers. ABT-199, the first specific Bcl-2 inhibitor, was approved by FDA for the treatment of several...
8.
Tito C, Genovese I, Giamogante F, Benedetti A, Miglietta S, Barazzuol L, et al.
Cell Mol Life Sci
. 2023 Jul;
80(8):202.
PMID: 37442828
The epidermal growth factor receptor (EGFR) is one of the main tumor drivers and is an important therapeutic target for many cancers. Calcium is important in EGFR signaling pathways. Sorcin...
9.
Zwergel C, Aventaggiato M, Garbo S, Di Bello E, Fassari B, Noce B, et al.
J Med Chem
. 2023 Jul;
66(14):9622-9641.
PMID: 37439550
The mitochondrial SIRT3 modulates several biological pathways such as cancer, metabolism, and hypoxia-related diseases. Recently, we discovered new 1,4-dihydropyridines, compounds and , the latter being a SIRT3-specific activator. In the...
10.
Pascarella G, Antonelli L, Narzi D, Battista T, Fiorillo A, Colotti G, et al.
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047338
The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in a variety of central nervous system disorders and whose agonists have neuroprotective activity. In spite of...