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Gianluigi Guidotti

Explore the profile of Gianluigi Guidotti including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 318
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Recent Articles
1.
van der Doelen R, Calabrese F, Guidotti G, Geenen B, Riva M, Kozicz T, et al.
Front Behav Neurosci . 2014 Oct; 8:355. PMID: 25352794
The short allelic variant of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) has been associated with the etiology of major depression by interaction with early life stress (ELS). A...
2.
Calabrese F, van der Doelen R, Guidotti G, Racagni G, Kozicz T, Homberg J, et al.
J Neurochem . 2014 Aug; 132(1):146-54. PMID: 25087780
Although the causes of psychiatric disorders are not fully understood, it is well established that mental illness originates from the interaction between genetic and environmental factors. In this regard, compelling...
3.
Calabrese F, Guidotti G, Racagni G, Riva M
Neurobiol Aging . 2013 Jul; 34(12):2768-76. PMID: 23870838
Aging is a physiological process characterized by a significant reduction of neuronal plasticity that might contribute to the functional defects observed in old subjects. Even if the neurobiological mechanisms that...
4.
Molteni R, Macchi F, Zecchillo C, DellAgli M, Colombo E, Calabrese F, et al.
Eur Neuropsychopharmacol . 2013 Apr; 23(11):1645-55. PMID: 23622958
Growing evidence suggests that the activation of the inflammatory/immune system contributes to depression pathogenesis, a hypothesis that might hold strong clinical implication. Indeed more than 30% of depressed patients fail...
5.
Calabrese F, Guidotti G, Middelman A, Racagni G, Homberg J, Riva M
Mol Neurobiol . 2013 Apr; 48(1):244-56. PMID: 23564488
It is well established that alterations of the serotoninergic system may contribute to the pathophysiology of mood disorders. Accordingly, it has been demonstrated that genetic deletion of the serotonin transporter...
6.
Guidotti G, Calabrese F, Anacker C, Racagni G, Pariante C, Riva M
Neuropsychopharmacology . 2012 Nov; 38(4):616-27. PMID: 23169346
Major depression is thought to originate from the interaction between susceptibility genes and adverse environmental events, in particular stress. The hypothalamus-pituitary-adrenal (HPA) axis is the major system involved in stress...
7.
Calabrese F, Guidotti G, Molteni R, Racagni G, Mancini M, Riva M
PLoS One . 2012 Jun; 7(5):e37916. PMID: 22666412
It is now well established that the glutamatergic system contributes to the pathophysiology of depression. Exposure to stress, a major precipitating factor for depression, enhances glutamate release that can contribute...
8.
Bertani M, Tansella M, Ruggeri M, Mirella M, Bonetto C, Cristofalo D, et al.
Trials . 2012 Jun; 13:73. PMID: 22647399
Background: Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP...
9.
Guidotti G, Calabrese F, Auletta F, Olivier J, Racagni G, Homberg J, et al.
Neuropsychopharmacology . 2011 Oct; 37(3):746-58. PMID: 22012473
Alterations of the serotonergic system are involved in the pathophysiology of mood disorders and represent an important target for its pharmacological treatment. Genetic deletion of the serotonin transporter (SERT) in...
10.
Alboni S, Montanari C, Benatti C, Blom J, Simone M, Brunello N, et al.
Brain Behav Immun . 2010 Nov; 25(3):483-93. PMID: 21111041
Interleukin (IL)-18 is a pro-inflammatory cytokine that is proposed to be involved in physiological as well as pathological conditions in the adult brain. IL-18 acts through a heterodimer receptor comprised...