Gian Carlo Demontis
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Explore the profile of Gian Carlo Demontis including associated specialties, affiliations and a list of published articles.
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28
Citations
390
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Recent Articles
11.
Betti L, Palego L, Demontis G, Miraglia F, Giannaccini G
Heliyon
. 2019 Nov;
5(9):e02417.
PMID: 31687544
Numerous pieces of evidence support the expression by the mammalian retina of Hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4), the enzyme directly responsible for the biosynthesis of the pineal chronobiotic hormone melatonin (MLT)....
12.
Giannelli S, Luoni M, Castoldi V, Massimino L, Cabassi T, Angeloni D, et al.
Hum Mol Genet
. 2017 Dec;
27(5):761-779.
PMID: 29281027
P23H is the most common mutation in the RHODOPSIN (RHO) gene leading to a dominant form of retinitis pigmentosa (RP), a rod photoreceptor degeneration that invariably causes vision loss. Specific...
13.
Caputo A, Piano I, Demontis G, Bacchi N, Casarosa S, Santina L, et al.
Front Cell Neurosci
. 2015 Nov;
9:422.
PMID: 26557056
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC). This event triggers...
14.
Bacchi N, Messina A, Burtscher V, Dassi E, Provenzano G, Bozzi Y, et al.
Invest Ophthalmol Vis Sci
. 2015 Jul;
56(8):4846-56.
PMID: 26218913
Purpose: Mutations in CACNA2D4 exon 25 cause photoreceptor dysfunction in humans (c.2406C→A mutation) and mice (c.2451insC mutation). We investigated the feasibility of an exon-skipping therapeutic approach by evaluating the splicing...
15.
Demontis G, Aruta C, Comitato A, De Marzo A, Marigo V
PLoS One
. 2012 Mar;
7(3):e33338.
PMID: 22432014
In vitro generation of photoreceptors from stem cells is of great interest for the development of regenerative medicine approaches for patients affected by retinal degeneration and for high throughput drug...
16.
Giannelli S, Demontis G, Pertile G, Rama P, Broccoli V
Stem Cells
. 2011 Jul;
29(2):344-56.
PMID: 21732491
There is growing evidence that Müller glia cells (MGCs) might act as regenerative elements in injured retinas of fishes and amniotes. However, their differentiation potential in humans is yet unknown....
17.
Longoni B, Szilagyi E, Quaranta P, Paoli G, Tripodi S, Urbani S, et al.
Diabetes Technol Ther
. 2010 May;
12(6):435-46.
PMID: 20470228
Background: Pancreatic islet transplantation is a promising cell-based therapy for type 1 diabetes (insulin-dependent diabetes mellitus), a disease triggered by the immune response against autoantigens of beta-cells. However, the recurrence...
18.
Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents
Santina L, Bouly M, Asta A, Demontis G, Cervetto L, Gargini C
Invest Ophthalmol Vis Sci
. 2009 Sep;
51(2):1016-23.
PMID: 19741244
Purpose: To elucidate short- and long-term effects of ivabradine, an inhibitor of the hyperpolarization-activated current (I(f)) recently approved for treatment of stable angina, on retinal function and integrity. As careful...
19.
Lan L, Vitobello A, Bertacchi M, Cremisi F, Vignali R, Andreazzoli M, et al.
Stem Cells
. 2009 Jul;
27(9):2146-52.
PMID: 19591225
Driving specific differentiation pathways in multipotent stem cells is a main goal of cell therapy. Here we exploited the differentiating potential of Xenopus animal cap embryonic stem (ACES) cells to...
20.
Demontis G, Gargini C, Paoli T, Cervetto L
Invest Ophthalmol Vis Sci
. 2008 Dec;
50(4):1948-55.
PMID: 19060291
Purpose: To evaluate in mammalian rod photoreceptors the selectivity for hyperpolarization-activated cyclic nucleotide-gated (Hcn1, coded by Hcn1) over potassium-selective (Kir 2.4, coded by Kcnj14) channels of ivabradine, a selective inhibitor...