Giada Rossignoli
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Explore the profile of Giada Rossignoli including associated specialties, affiliations and a list of published articles.
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14
Citations
99
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Recent Articles
1.
Cesana M, Tufano G, Panariello F, Zampelli N, Soldati C, Mutarelli M, et al.
Cell Death Differ
. 2024 Jul;
31(11):1439-1451.
PMID: 38965447
TFEB, a bHLH-leucine zipper transcription factor belonging to the MiT/TFE family, globally modulates cell metabolism by regulating autophagy and lysosomal functions. Remarkably, loss of TFEB in mice causes embryonic lethality...
2.
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis
Lo Conte M, Lucchino V, Scalise S, Zannino C, Valente D, Rossignoli G, et al.
Stem Cell Reports
. 2024 May;
19(5):729-743.
PMID: 38701777
Embryonic stem cells (ESCs) are defined as stem cells with self-renewing and differentiation capabilities. These unique properties are tightly regulated and controlled by complex genetic and molecular mechanisms, whose understanding...
3.
Abela L, Gianfrancesco L, Tagliatti E, Rossignoli G, Barwick K, Zourray C, et al.
Brain
. 2024 Jan;
147(6):2023-2037.
PMID: 38242634
DNAJC6 encodes auxilin, a co-chaperone protein involved in clathrin-mediated endocytosis (CME) at the presynaptic terminal. Biallelic mutations in DNAJC6 cause a complex, early-onset neurodegenerative disorder characterized by rapidly progressive parkinsonism-dystonia...
4.
Bisello G, Rossignoli G, Choi S, Phillips R, Bertoldi M
Biochem Biophys Res Commun
. 2023 Aug;
679:6-14.
PMID: 37651872
Aromatic amino acid decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme responsible for the synthesis of the neurotransmitters, dopamine and serotonin. Here, by a combination of bioinformatic predictions and analyses, phosphorylation assays,...
5.
Zorzan I, Betto R, Rossignoli G, Arboit M, Drusin A, Corridori C, et al.
EMBO Rep
. 2023 Feb;
24(4):e55235.
PMID: 36847616
In human embryos, naive pluripotent cells of the inner cell mass (ICM) generate epiblast, primitive endoderm and trophectoderm (TE) lineages, whence trophoblast cells derive. In vitro, naive pluripotent stem cells...
6.
McTague A, Rossignoli G, Ferrini A, Barral S, Kurian M
Front Genome Ed
. 2021 Oct;
3:630600.
PMID: 34713254
Therapeutic advances for neurological disorders are challenging due to limited accessibility of the human central nervous system and incomplete understanding of disease mechanisms. Many neurological diseases lack precision treatments, leading...
7.
Ng J, Barral S, De La Fuente Barrigon C, Lignani G, Erdem F, Wallings R, et al.
Sci Transl Med
. 2021 May;
13(594).
PMID: 34011628
Most inherited neurodegenerative disorders are incurable, and often only palliative treatment is available. Precision medicine has great potential to address this unmet clinical need. We explored this paradigm in dopamine...
8.
Rossignoli G, Kramer K, Lugara E, Alrashidi H, Pope S, De La Fuente Barrigon C, et al.
Brain
. 2021 Mar;
144(8):2443-2456.
PMID: 33734312
Aromatic l-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The majority of affected individuals have variable, though...
9.
Bisello G, Longo C, Rossignoli G, Phillips R, Bertoldi M
Amino Acids
. 2020 Aug;
52(8):1089-1105.
PMID: 32844248
The versatility of reactions catalyzed by pyridoxal 5'-phosphate (PLP) enzymes is largely due to the chemistry of their extraordinary catalyst. PLP is necessary for many reactions involving amino acids. Reaction...
10.
Montioli R, Bisello G, Dindo M, Rossignoli G, Borri Voltattorni C, Bertoldi M
Arch Biochem Biophys
. 2020 Jan;
682:108263.
PMID: 31953134
AADC deficiency is a rare genetic disease caused by mutations in the gene of aromatic amino acid decarboxylase, the pyridoxal 5'-phosphate dependent enzyme responsible for the synthesis of dopamine and...