Gert Jan C Veenstra
Overview
Explore the profile of Gert Jan C Veenstra including associated specialties, affiliations and a list of published articles.
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58
Citations
2443
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Recent Articles
1.
Snabel R, Cofino-Fabres C, Baltissen M, Schwach V, Passier R, Veenstra G
Stem Cell Reports
. 2025 Feb;
20(3):102422.
PMID: 40020683
Stem cell-based models of human heart tissue and cardiac differentiation employ monolayer and 3D organoid cultures with different properties, cell type composition, and maturity. Here we show how cardiac monolayer,...
2.
van Loo B, Ten Den S, Araujo-Gomes N, de Jong V, Snabel R, Schot M, et al.
Nat Commun
. 2023 Oct;
14(1):6685.
PMID: 37865642
Organoids are engineered 3D miniature tissues that are defined by their organ-like structures, which drive a fundamental understanding of human development. However, current organoid generation methods are associated with low...
3.
Luna Velez M, Neikes H, Snabel R, Quint Y, Qian C, Martens A, et al.
Nucleic Acids Res
. 2023 Jan;
51(3):1277-1296.
PMID: 36625255
Microfold (M) cells reside in the intestinal epithelium of Peyer's patches (PP). Their unique ability to take up and transport antigens from the intestinal lumen to the underlying lymphoid tissue...
4.
Loh C, Veenstra G
Epigenomes
. 2022 Aug;
6(3).
PMID: 35997369
Embryonic development is a highly intricate and complex process. Different regulatory mechanisms cooperatively dictate the fate of cells as they progress from pluripotent stem cells to terminally differentiated cell types...
5.
Nakayama T, Roubroeks J, Veenstra G, Grainger R
Cold Spring Harb Protoc
. 2022 Aug;
2022(12):641-652.
PMID: 35953244
Single-cell omics such as single-cell RNA-sequencing (RNA-seq) have been used extensively to obtain single-cell genome-wide expression data. This technique can be used to compare mutant and wild-type embryos at predifferentiation...
6.
Jansen C, Paraiso K, Zhou J, Blitz I, Fish M, Charney R, et al.
Cell Rep
. 2022 Feb;
38(7):110364.
PMID: 35172134
Mesendodermal specification is one of the earliest events in embryogenesis, where cells first acquire distinct identities. Cell differentiation is a highly regulated process that involves the function of numerous transcription...
7.
Harlaar N, Dekker S, Zhang J, Snabel R, Veldkamp M, Verkerk A, et al.
Nat Biomed Eng
. 2022 Jan;
6(4):389-402.
PMID: 34992271
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional...
8.
Loh C, van Genesen S, Perino M, Bark M, Veenstra G
Nat Commun
. 2021 Dec;
12(1):6985.
PMID: 34848733
Polycomb Repressive Complex 2 (PRC2) is crucial for the coordinated expression of genes during early embryonic development, catalyzing histone H3 lysine 27 trimethylation. Two distinct PRC2 complexes, PRC2.1 and PRC2.2,...
9.
Xu Q, Georgiou G, Frolich S, van der Sande M, Veenstra G, Zhou H, et al.
Nucleic Acids Res
. 2021 Jul;
49(14):7966-7985.
PMID: 34244796
Proper cell fate determination is largely orchestrated by complex gene regulatory networks centered around transcription factors. However, experimental elucidation of key transcription factors that drive cellular identity is currently often...
10.
Bright A, van Genesen S, Li Q, Grasso A, Frolich S, van der Sande M, et al.
EMBO J
. 2021 Feb;
40(9):e104913.
PMID: 33555045
During vertebrate gastrulation, mesoderm is induced in pluripotent cells, concomitant with dorsal-ventral patterning and establishing of the dorsal axis. We applied single-cell chromatin accessibility and transcriptome analyses to explore the...