Gerhard Paul Puschel
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Explore the profile of Gerhard Paul Puschel including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
154
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Recent Articles
1.
LDL-Dependent Regulation of TNFα/PGE Induced COX-2/mPGES-1 Expression in Human Macrophage Cell Lines
Neuschafer-Rube F, Schon T, Kahnt I, Puschel G
Inflammation
. 2023 Jan;
46(3):893-911.
PMID: 36598592
Inflammation is a hallmark in severe diseases such as atherosclerosis and non-alcohol-induced steatohepatitis (NASH). In the development of inflammation, prostaglandins, especially prostaglandin E (PGE), are major players alongside with chemo-...
2.
Schjeide B, Puschel G
Curr Protoc
. 2023 Jan;
3(1):e635.
PMID: 36598341
Double-control quantitative copy number PCR (dc-qcnPCR) is a recently described tool that can be used to quantify donor DNA insertions in genetically modified monoclonal cell lines. In conjunction with an...
3.
Puschel G, Klauder J, Henkel J
J Clin Med
. 2022 Aug;
11(15).
PMID: 35955975
Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which present a very heterogeneous population of cells, play a key...
4.
Schjeide B, Schenke M, Seeger B, Puschel G
Methods Protoc
. 2022 Jun;
5(3).
PMID: 35736544
In order to improve a recently established cell-based assay to assess the potency of botulinum neurotoxin, neuroblastoma-derived SiMa cells and induced pluripotent stem-cells (iPSC) were modified to incorporate the coding...
5.
Henkel J, Klauder J, Statz M, Wohlenberg A, Kuipers S, Vahrenbrink M, et al.
Biomedicines
. 2021 Apr;
9(5).
PMID: 33919366
Macrophages in pathologically expanded dysfunctional white adipose tissue are exposed to a mix of potential modulators of inflammatory response, including fatty acids released from insulin-resistant adipocytes, increased levels of insulin...
6.
Klauder J, Henkel J, Vahrenbrink M, Wohlenberg A, Camargo R, Puschel G
Cytokine
. 2020 Aug;
136:155241.
PMID: 32799102
Overweight and obesity are accompanied by insulin resistance, impaired intestinal barrier function resulting in increased lipopolysaccharide (LPS) levels, and a low-grade chronic inflammation that results in macrophage activation. Macrophages produce...
7.
Gehre C, Flechner M, Kammerer S, Kupper J, Coleman C, Puschel G, et al.
Sci Rep
. 2020 Aug;
10(1):13700.
PMID: 32792676
Most in vitro test systems for the assessment of toxicity are based on endpoint measurements and cannot contribute much to the establishment of mechanistic models, which are crucially important for...
8.
Henkel J, Coleman C, Schraplau A, Johrens K, Weiss T, Jonas W, et al.
Sci Rep
. 2018 Nov;
8(1):16127.
PMID: 30382148
In a subset of patients, non-alcoholic fatty liver disease (NAFLD) is complicated by cell death and inflammation resulting in non-alcoholic steatohepatitis (NASH), which may progress to fibrosis and subsequent organ...
9.
Pathe-Neuschafer-Rube A, Neuschafer-Rube F, Haas G, Langoth-Fehringer N, Puschel G
Toxins (Basel)
. 2018 Sep;
10(9).
PMID: 30189643
Despite the implementation of cell-based replacement methods, the mouse lethality assay is still frequently used to determine the activity of botulinum toxin (BoNT) for medical use. One explanation is that...
10.
Henkel J, Coleman C, Schraplau A, Jhrens K, Weber D, Castro J, et al.
Mol Med
. 2017 Mar;
23:70-82.
PMID: 28332698
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or...