Gerard P Sergeant
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Explore the profile of Gerard P Sergeant including associated specialties, affiliations and a list of published articles.
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59
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526
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Recent Articles
1.
Mercer M, Hollywood M, Sergeant G, Thornbury K
Am J Physiol Cell Physiol
. 2025 Jan;
328(3):C729-C742.
PMID: 39828508
Adrenergic stimulation induces contractions in the corpus cavernosum smooth muscle (CCSM), which are important in maintaining penile flaccidity. The aim of this study was to investigate the role of K7...
2.
Ghosh S, Alkawadri T, McGarvey L, Hollywood M, Thornbury K, Sergeant G
Am J Physiol Lung Cell Mol Physiol
. 2025 Jan;
328(2):L301-L312.
PMID: 39772966
Cholinergic tone is elevated in obstructive lung conditions such as chronic obstructive pulmonary disease (COPD) and asthma, but the cellular mechanisms underlying cholinergic contractions of airway smooth muscle (ASM) are...
3.
Lim X, Mercer M, Harraz O, Hollywood M, Sergeant G, Thornbury K
J Sex Med
. 2024 Sep;
21(11):977-985.
PMID: 39234981
Background: Evidence suggests that the corpus cavernosum smooth muscle (CCSM) cells of several species, including humans, express purinergic P2X receptors, but it is not known if the corpus cavernosum has...
4.
Gupta N, Baker S, Sanders K, Griffin C, Sergeant G, Hollywood M, et al.
Cell Calcium
. 2024 Jul;
123:102931.
PMID: 39068674
Urethral smooth muscle cells (USMC) contract to occlude the internal urethral sphincter during bladder filling. Interstitial cells also exist in urethral smooth muscles and are hypothesized to influence USMC behaviours...
5.
Dunne O, Martin S, Sergeant G, McAuley D, OKane C, Button B, et al.
Respir Res
. 2024 Apr;
25(1):188.
PMID: 38678280
Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may...
6.
Wong P, Fong Z, Hollywood M, Thornbury K, Sergeant G
Purinergic Signal
. 2024 Feb;
20(5):547-557.
PMID: 38374492
Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient component resulting from activation of P2X1 receptors by ATP and a secondary sustained component...
7.
OuYang X, Reihill J, Douglas L, Dunne O, Sergeant G, Martin S
Biochim Biophys Acta Mol Basis Dis
. 2024 Feb;
1870(4):167079.
PMID: 38367901
Type 2 inflammation in asthma develops with exposure to stimuli to include inhaled allergens from house dust mites (HDM). Features include mucus hypersecretion and the formation of pro-secretory ion transport...
8.
Matthews R, Bradley E, Hollywood M, Lundy F, McGarvey L, Sergeant G, et al.
Am J Physiol Cell Physiol
. 2023 Nov;
326(1):C1-C9.
PMID: 37955124
Airway smooth muscle (ASM) cells from mouse bronchus express a fast sodium current mediated by Na1.7. We present evidence that this current is regulated by cAMP. ASM cells were isolated...
9.
Fong Z, Lall A, Mullins N, Santana L, Hollywood M, Thornbury K, et al.
Basic Clin Pharmacol Toxicol
. 2023 May;
133(1):29-42.
PMID: 37125918
Purinergic contractions of the detrusor are reduced by cAMP, but the underlying mechanisms are unclear. We examined the effects of BK and Kv7 channel modulators on purinergic contractions of the...
10.
Dwivedi R, Drumm B, Alkawadri T, Martin S, Sergeant G, Hollywood M, et al.
Eur J Pharmacol
. 2023 Mar;
947:175677.
PMID: 36967079
We investigated effects of TMEM16A blockers benzbromarone, MONNA, CaCCA01 and Ani9 on isometric contractions in mouse bronchial rings and on intracellular calcium in isolated bronchial myocytes. Separate concentrations of carbachol...