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» Authors » Gerald M Alter

Gerald M Alter

Explore the profile of Gerald M Alter including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 93
Followers 0
Related Specialties
Biochemistry
Neurology
Pharmacology
Top 10 Co-Authors
Jonathan E Nuss
Krystyna B Wieczerzak
Thomas L Brown
Jarek Meller
Jacob G Robison
Dawn P Wooley
S Dean Rider Jr
Kathleen Dixon
Michael A Lepera
Kelly J Huang
Published In
Biochemistry
J Neurovirol
Cell Physiol Biochem
J Biol Chem
Protein Sci
Affiliations
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Recent Articles
1.
Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg, spermine, and pH
Zhelay T, Wieczerzak K, Beesetty P, Alter G, Matsushita M, Kozak J
J Biol Chem . 2018 Oct; 293(47):18151-18167. PMID: 30305398
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ion channel/protein kinase belonging to the TRP melastatin and eEF2 kinase families. Under physiological conditions, most native TRPM7...
2.
Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway
Xu Y, Singh A, Alter G
Genetics . 2016 Sep; 204(3):959-973. PMID: 27585850
Hydroxyurea (HU) has been used for the treatment of multiple diseases, such as cancer. The therapeutic effect is generally believed to be due to the suppression of ribonucleotide reductase (RNR),...
3.
A single amino acid change humanizes long-chain fatty acid binding and activation of mouse peroxisome proliferator-activated receptor α
Oswal D, Alter G, Rider Jr S, Hostetler H
J Mol Graph Model . 2014 May; 51:27-36. PMID: 24858253
Peroxisome proliferator-activated receptor α (PPARα) is an important regulator of hepatic lipid metabolism which functions through ligand binding. Despite high amino acid sequence identity (>90%), marked differences in PPARα ligand...
4.
Canonical Bcl-2 motifs of the Na+/K+ pump revealed by the BH3 mimetic chelerythrine: early signal transducers of apoptosis?
Lauf P, Heiny J, Meller J, Lepera M, Koikov L, Alter G, et al.
Cell Physiol Biochem . 2013 Mar; 31(2-3):257-76. PMID: 23466888
Background/aims: Chelerythrine [CET], a protein kinase C [PKC] inhibitor, is a prop-apoptotic BH3-mimetic binding to BH1-like motifs of Bcl-2 proteins. CET action was examined on PKC phosphorylation-dependent membrane transporters (Na+/K+...
5.
Reactivity-based analysis of domain structures in native replication protein A
Nuss J, Sweeney D, Alter G
Biochemistry . 2006 Aug; 45(32):9804-18. PMID: 16893181
Replication protein A (RPA) is an essential heterotrimeric ssDNA binding protein that participates in DNA repair, replication, and recombination. Though X-ray and NMR experiments have been used to determine three-dimensional...
6.
DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage
Nuss J, Patrick S, Oakley G, Alter G, Robison J, Dixon K, et al.
Biochemistry . 2005 Jun; 44(23):8428-37. PMID: 15938632
Replication protein A (RPA) is the predominant eukaryotic single-stranded DNA binding protein composed of 70, 34, and 14 kDa subunits. RPA plays central roles in the processes of DNA replication,...
7.
Denaturation of replication protein A reveals an alternative conformation with intact domain structure and oligonucleotide binding activity
Nuss J, Alter G
Protein Sci . 2004 Apr; 13(5):1365-78. PMID: 15096638
Replication protein A (RPA) is a heterotrimeric, multidomain, single-stranded DNA-binding protein. Using spectroscopic methods and methylene carbene-based chemical modification methods, we have identified conformational intermediates in the denaturation pathway of...
8.
The reverse transcriptase sequence of human immunodeficiency virus type 1 is under positive evolutionary selection within the central nervous system
Huang K, Alter G, Wooley D
J Neurovirol . 2002 Aug; 8(4):281-94. PMID: 12161813
The human immunodeficiency virus type 1 (HIV-1) enters the central nervous system (CNS) during the acute phase of infection and causes AIDS-related encephalitis and dementia in 30% of individuals. Previous...