Gerald C Tiu
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Explore the profile of Gerald C Tiu including associated specialties, affiliations and a list of published articles.
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7
Citations
388
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Recent Articles
1.
Tiu G, Natkunam Y, Fernandez-Pol S
J Hematop
. 2024 Jan;
16(2):119-122.
PMID: 38175442
No abstract available.
2.
Genuth N, Shi Z, Kunimoto K, Hung V, Xu A, Kerr C, et al.
Nat Commun
. 2022 Sep;
13(1):5491.
PMID: 36123354
Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types or control cell fate remains unknown. Here, employing quantitative mass spectrometry during...
3.
Leppek K, Byeon G, Kladwang W, Wayment-Steele H, Kerr C, Xu A, et al.
Nat Commun
. 2022 Mar;
13(1):1536.
PMID: 35318324
Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we...
4.
Tiu G, Kerr C, Forester C, Krishnarao P, Rosenblatt H, Raj N, et al.
Dev Cell
. 2021 Jul;
56(14):2089-2102.e11.
PMID: 34242585
In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as a result of mutations in the ribosome, a ubiquitous cellular machine, has...
5.
Leppek K, Byeon G, Kladwang W, Wayment-Steele H, Kerr C, Xu A, et al.
bioRxiv
. 2021 Apr;
PMID: 33821271
Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we...
6.
Simsek D, Tiu G, Flynn R, Byeon G, Leppek K, Xu A, et al.
Cell
. 2017 Jun;
169(6):1051-1065.e18.
PMID: 28575669
During eukaryotic evolution, ribosomes have considerably increased in size, forming a surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an interface for yet uncharacterized interacting proteins. To...
7.
Kleiner R, Dumelin C, Tiu G, Sakurai K, Liu D
J Am Chem Soc
. 2010 Aug;
132(33):11779-91.
PMID: 20681606
DNA-templated organic synthesis enables the translation of DNA sequences into synthetic small-molecule libraries suitable for in vitro selection. Previously, we described the DNA-templated multistep synthesis of a 13,824-membered small-molecule macrocycle...