Georgios Kalamakis
Overview
Explore the profile of Georgios Kalamakis including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
993
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Recent Articles
1.
Santinha A, Klingler E, Kuhn M, Farouni R, Lagler S, Kalamakis G, et al.
Nature
. 2023 Sep;
622(7982):367-375.
PMID: 37730998
The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype-phenotype relationships in complex tissues in a high-throughput manner. Here we introduce adeno-associated virus (AAV)-mediated...
2.
Kalamakis G, Platt R
Neuron
. 2023 May;
111(15):2282-2311.
PMID: 37201524
Genome engineering technologies provide an entry point into understanding and controlling the function of genetic elements in health and disease. The discovery and development of the microbial defense system CRISPR-Cas...
3.
Kalamakis G, Brune D, Ravichandran S, Bolz J, Fan W, Ziebell F, et al.
Cell
. 2019 Mar;
176(6):1407-1419.e14.
PMID: 30827680
The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the...
4.
Baser A, Skabkin M, Kleber S, Dang Y, Gulculer Balta G, Kalamakis G, et al.
Nature
. 2019 Feb;
566(7742):100-104.
PMID: 30700908
Whether post-transcriptional regulation of gene expression controls differentiation of stem cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein synthesis, which is key to...
5.
Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, et al.
J Cell Sci
. 2018 Aug;
131(18).
PMID: 30131441
Cilia perform essential signalling functions during development and tissue homeostasis. A key event in ciliogenesis occurs when the distal appendages of the mother centriole form a platform that docks ciliary...
6.
Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, et al.
Development
. 2017 Oct;
144(24):4604-4615.
PMID: 29061639
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the establishment of the neuromuscular junction. Here, we show that LRP4 is also expressed by embryonic cortical...
7.
Stylianopoulou E, Kalamakis G, Pitsiani M, Fysekis I, Ypsilantis P, Simopoulos C, et al.
Histochem Cell Biol
. 2015 Nov;
145(2):175-84.
PMID: 26537243
Winged helix proteins have critical roles in a variety of developmental processes. During a screening for genes expressed in the developing forebrain, we identified HSPC280, a non-typical winged helix protein,...
8.
Osswald M, Jung E, Sahm F, Solecki G, Venkataramani V, Blaes J, et al.
Nature
. 2015 Nov;
528(7580):93-8.
PMID: 26536111
Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct...
9.
Thestrup T, Litzlbauer J, Bartholomaus I, Mues M, Russo L, Dana H, et al.
Nat Methods
. 2014 Jan;
11(2):175-82.
PMID: 24390440
The quality of genetically encoded calcium indicators (GECIs) has improved dramatically in recent years, but high-performing ratiometric indicators are still rare. Here we describe a series of fluorescence resonance energy...