Georgina C Fletcher
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Explore the profile of Georgina C Fletcher including associated specialties, affiliations and a list of published articles.
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13
Citations
461
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Recent Articles
1.
Bonello T, Cai D, Fletcher G, Wiengartner K, Pengilly V, Lange K, et al.
EMBO J
. 2023 Feb;
42(6):e112863.
PMID: 36807601
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the...
2.
Aguilar-Aragon M, Bonello T, Bell G, Fletcher G, Thompson B
EMBO Rep
. 2020 Feb;
21(4):e49700.
PMID: 32030856
Epithelial cells undergo cortical rounding at the onset of mitosis to enable spindle orientation in the plane of the epithelium. In cuboidal epithelia in culture, the adherens junction protein E-cadherin...
3.
Sidor C, Borreguero-Munoz N, Fletcher G, Elbediwy A, Guillermin O, Thompson B
Elife
. 2019 Oct;
8.
PMID: 31661072
Mask family proteins were discovered in to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function...
4.
Borreguero-Munoz N, Fletcher G, Aguilar-Aragon M, Elbediwy A, Vincent-Mistiaen Z, Thompson B
PLoS Biol
. 2019 Oct;
17(10):e3000509.
PMID: 31613895
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain-containing transcriptional activator [WWTR1]),...
5.
Aguilar-Aragon M, Elbediwy A, Foglizzo V, Fletcher G, Li V, Thompson B
Cell Rep
. 2018 Feb;
22(7):1639-1646.
PMID: 29444419
Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss...
6.
Fletcher G, Diaz-de-la-Loza M, Borreguero-Munoz N, Holder M, Aguilar-Aragon M, Thompson B
Development
. 2018 Feb;
145(5).
PMID: 29440303
Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole homolog of which is named Yorkie (Yki). In mammalian...
7.
Khanal I, Elbediwy A, Diaz de la Loza M, Fletcher G, Thompson B
J Cell Sci
. 2017 Jul;
130(13):2221.
PMID: 28668933
No abstract available.
8.
Khanal I, Elbediwy A, Diaz de la Loza M, Fletcher G, Thompson B
J Cell Sci
. 2016 May;
129(13):2651-9.
PMID: 27231092
In epithelial tissues, polarisation of microtubules and actin microvilli occurs along the apical-basal axis of each cell, yet how these cytoskeletal polarisation events are coordinated remains unclear. Here, we examine...
9.
Ivanova M, Fletcher G, OReilly N, Purkiss A, Thompson B, McDonald N
Acta Crystallogr D Biol Crystallogr
. 2015 Mar;
71(Pt 3):555-64.
PMID: 25760605
Many components of epithelial polarity protein complexes possess PDZ domains that are required for protein interaction and recruitment to the apical plasma membrane. Apical localization of the Crumbs (Crb) transmembrane...
10.
Fletcher G, Elbediwy A, Khanal I, Ribeiro P, Tapon N, Thompson B
EMBO J
. 2015 Feb;
34(7):940-54.
PMID: 25712476
The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing...