George Orphanides
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Explore the profile of George Orphanides including associated specialties, affiliations and a list of published articles.
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1322
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Recent Articles
1.
Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, et al.
Int J Cancer
. 2013 Jul;
134(3):552-62.
PMID: 23852808
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of...
2.
Schlicker A, Beran G, Chresta C, McWalter G, Pritchard A, Weston S, et al.
BMC Med Genomics
. 2013 Jan;
5:66.
PMID: 23272949
Background: Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with...
3.
Mainwaring G, Lim F, Antrobus K, Swain C, Clapp M, Kimber I, et al.
Toxicology
. 2006 Jul;
225(2-3):157-72.
PMID: 16854511
We have used global gene expression profiling, combined with pathway analysis tools, to identify in rats the molecular events associated with paraquat toxicity in the lung. Early (2, 8 and...
4.
Stuckey R, Aldridge T, Lim F, Moore D, Tinwell H, Doherty N, et al.
Mol Cell Endocrinol
. 2006 May;
253(1-2):22-9.
PMID: 16684588
We have previously used genome-wide transcript profiling to investigate the relationships between changes in gene expression and physiological alterations during the response of the immature mouse uterus to estrogens. Here...
5.
Corvi R, Ahr H, Albertini S, Blakey D, Clerici L, Coecke S, et al.
Environ Health Perspect
. 2006 Mar;
114(3):420-9.
PMID: 16507466
This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the...
6.
MacDonald N, Welburn J, Noble M, Nguyen A, Yaffe M, Clynes D, et al.
Mol Cell
. 2005 Oct;
20(2):199-211.
PMID: 16246723
Phosphorylation of histone H3 is implicated in transcriptional activation and chromosome condensation, but its immediate molecular function has remained obscure. By affinity chromatography of nuclear extracts against modified H3 tail...
7.
Currie R, Orphanides G, Moggs J
Reprod Toxicol
. 2005 Jun;
20(3):433-40.
PMID: 15964738
The recent sequencing of mammalian genomes has driven the development of genomic technologies, including microarray-based gene expression profiling, that allow simultaneous measurement of the expression levels of thousands of genes....
8.
Currie R, Bombail V, Oliver J, Moore D, Lim F, Gwilliam V, et al.
Toxicol Sci
. 2005 May;
86(2):453-69.
PMID: 15901911
Toxicogenomics has the potential to reveal the molecular pathways and cellular processes that mediate the adverse responses to a toxicant. However, the initial output of a toxicogenomic experiment often consists...
9.
Moggs J, Tinwell H, Spurway T, Chang H, Pate I, Lim F, et al.
Environ Health Perspect
. 2004 Dec;
112(16):1589-606.
PMID: 15598610
A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical...
10.
Moggs J, Ashby J, Tinwell H, Lim F, Moore D, Kimber I, et al.
Environ Health Perspect
. 2004 Aug;
112(11):1137-42.
PMID: 15289156
We used gene expression profiling to investigate whether the molecular effects induced by estrogens of different provenance are intrinsically similar. In this article we show that the physiologic estrogen 17-beta-estradiol,...