George Doherty
Overview
Explore the profile of George Doherty including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
206
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0
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Recent Articles
1.
Judd A, Bawa B, Buck W, Tao Z, Li Y, Mitten M, et al.
Sci Adv
. 2024 Oct;
10(40):eado7120.
PMID: 39365864
Overexpression of the antiapoptotic protein B-cell lymphoma-extra large (BCL-X) is associated with drug resistance and disease progression in numerous cancers. The compelling nature of this protein as a therapeutic target...
2.
Reis de Andrade J, Scourfield E, Peswani-Sajnani S, Poulton K, Ap Rees T, Khooshemehri P, et al.
Biol Methods Protoc
. 2024 Jul;
9(1):bpae046.
PMID: 38993523
Rapid and accessible testing was paramount in the management of the COVID-19 pandemic. Our university established KCL TEST: a SARS-CoV-2 asymptomatic testing programme that enabled sensitive and accessible PCR testing...
3.
Rynne J, Ortiz-Zapater E, Bagley D, Zanin O, Doherty G, Kanabar V, et al.
Front Cell Dev Biol
. 2023 Nov;
11:1241008.
PMID: 37928904
Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA...
4.
Eyre D, Lumley S, ODonnell D, Campbell M, Sims E, Lawson E, et al.
Elife
. 2020 Aug;
9.
PMID: 32820721
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence...
5.
Scott V, Vortherms T, Niforatos W, Swensen A, Neelands T, Milicic I, et al.
Biochem Pharmacol
. 2011 Dec;
83(3):406-18.
PMID: 22153861
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant antinociception...
6.
Yan L, Huo P, Doherty G, Toth L, Hale J, Mills S, et al.
Bioorg Med Chem Lett
. 2006 May;
16(14):3679-83.
PMID: 16697189
A series of 3-arylpropionic acids were synthesized as S1P1 receptor agonists. Structure-activity relationship studies on the pendant phenyl ring revealed several structural features offering selectivity of S1P1 binding against S1P2-5....
7.
Hale J, Doherty G, Toth L, Mills S, Hajdu R, Keohane C, et al.
Bioorg Med Chem Lett
. 2004 Jun;
14(13):3501-5.
PMID: 15177461
Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do...
8.
Hale J, Doherty G, Toth L, Li Z, Mills S, Hajdu R, et al.
Bioorg Med Chem Lett
. 2004 Jun;
14(13):3495-9.
PMID: 15177460
3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.
9.
Koo G, Shah K, Ding G, Xiao J, Wnek R, Doherty G, et al.
Am J Respir Crit Care Med
. 2003 Feb;
167(10):1400-9.
PMID: 12569079
A nonpeptidyl small molecule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in lung inflammation induced by a single dose of ovalbumin challenge. Compound A presented a...