George D Mellick
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Explore the profile of George D Mellick including associated specialties, affiliations and a list of published articles.
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130
Citations
3076
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Recent Articles
1.
Landoulsi Z, Ashok Kumar Sreelatha A, Schulte C, Bobbili D, Montanucci L, Leu C, et al.
medRxiv
. 2024 Sep;
PMID: 39228715
Objective: Our study investigates the impact of copy number variations (CNVs) on Parkinson's disease (PD) pathogenesis using genome-wide data, aiming to uncover novel genetic mechanisms and improve the understanding of...
2.
Domenighetti C, Sugier P, Ashok Kumar Sreelatha A, Schulte C, Grover S, Portugal B, et al.
Neurology
. 2024 Jul;
103(3):e209620.
PMID: 38986057
Background And Objectives: The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in PD...
3.
Makinde E, Ma L, Mellick G, Feng Y
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672457
Mitochondria, the energy hubs of the cell, are progressively becoming attractive targets in the search for potent therapeutics against neurodegenerative diseases. The pivotal role of mitochondrial dysfunction in the pathogenesis...
4.
Prebble D, Holland D, Ferretti F, Hayton J, Avery V, Mellick G, et al.
J Nat Prod
. 2023 Aug;
86(9):2171-2184.
PMID: 37610242
Amyloid protein aggregates are linked to the progression of neurodegenerative conditions and may play a role in life stages of , the parasite responsible for malaria. We hypothesize that amyloid...
5.
Muller-Nedebock A, Dekker M, Farrer M, Hattori N, Lim S, Mellick G, et al.
NPJ Parkinsons Dis
. 2023 Jul;
9(1):110.
PMID: 37443150
The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge,...
6.
Wang C, Nguyen T, Yang X, Mellick G, Feng Y
Bioorg Med Chem Lett
. 2023 Jun;
92:129386.
PMID: 37355024
Asarum sieboldii var. seoulense is a plant species under the family Aristolochiaceae and has been used for centuries as an ingredient in a well-known Traditional Chinese medicine (TCM), "Xixin", to...
7.
Hill M, Sykes A, Mellick G
J Neurosci Res
. 2023 Jun;
101(10):1611-1623.
PMID: 37334842
There are many cellular mechanisms implicated in the initiation and progression of neurodegenerative disorders. However, age and the accumulation of unwanted cellular products are a common theme underlying many neurodegenerative...
8.
Chen X, Feng Y, Quinn R, Pountney D, Richardson D, Mellick G, et al.
Pharmacol Rev
. 2023 Mar;
75(4):758-788.
PMID: 36918260
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain. The loss of neurons results...
9.
Makinde E, Ma L, Mellick G, Feng Y
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830595
Mitochondria are widely considered the "power hub" of the cell because of their pivotal roles in energy metabolism and oxidative phosphorylation. However, beyond the production of ATP, which is the...
10.
Sugier P, Lucotte E, Domenighetti C, Law M, Iles M, Brown K, et al.
Mov Disord
. 2023 Feb;
38(4):604-615.
PMID: 36788297
Background: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective: We used results from...