George C Gabriel
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Explore the profile of George C Gabriel including associated specialties, affiliations and a list of published articles.
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34
Citations
840
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Recent Articles
1.
Gabriel G, Yagi H, Tan T, Bais A, Glennon B, Stapleton M, et al.
Nat Commun
. 2025 Jan;
16(1):469.
PMID: 39774941
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease associated with microcephaly and poor neurodevelopmental outcomes. Here we show that the Ohia HLHS mouse model, with mutations in...
2.
Yagi H, Xu X, Gabriel G, Lo C
Adv Exp Med Biol
. 2024 Jun;
1441:947-961.
PMID: 38884763
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with underdevelopment of left-sided heart structures. While previously uniformly fatal, surgical advances now provide highly effective palliation that...
3.
Gabriel G, Lo C
Adv Exp Med Biol
. 2024 Jun;
1441:719-738.
PMID: 38884745
Left-right patterning is among the least well understood of the three axes defining the body plan, and yet it is no less important, with left-right patterning defects causing structural birth...
4.
Gabriel G, Wu Y, Lo C
Adv Exp Med Biol
. 2024 Jun;
1441:167-183.
PMID: 38884711
Formation of the vertebrate heart with its complex arterial and venous connections is critically dependent on patterning of the left-right axis during early embryonic development. Abnormalities in left-right patterning can...
5.
Gabriel G, Ganapathiraju M, Lo C
Annu Rev Genomics Hum Genet
. 2024 May;
25(1):309-327.
PMID: 38724024
Congenital heart disease (CHD) can affect up to 1% of live births, and despite abundant evidence of a genetic etiology, the genetic landscape of CHD is still not well understood....
6.
Gabriel G, Yagi H, Tan T, Bais A, Glennon B, Stapleton M, et al.
bioRxiv
. 2024 Mar;
PMID: 38464057
Poor neurodevelopment is often observed with congenital heart disease (CHD), especially with mutations in chromatin modifiers. Here analysis of mice with hypoplastic left heart syndrome (HLHS) arising from mutations in...
7.
Votava-Smith J, Gaesser J, Harbison A, Lee V, Tran N, Rajagopalan V, et al.
Front Neurosci
. 2022 Dec;
16:952355.
PMID: 36466162
Objective: Term congenital heart disease (CHD) neonates display abnormalities of brain structure and maturation, which are possibly related to underlying patient factors, abnormal physiology and perioperative insults. Our primary goal...
8.
Gabriel G, Devine W, Redel B, Whitworth K, Samuel M, Spate L, et al.
Sci Rep
. 2022 Sep;
12(1):16245.
PMID: 36171243
The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing...
9.
Gabriel G, Yagi H, Xu X, Lo C
World J Pediatr Congenit Heart Surg
. 2022 Sep;
13(5):565-570.
PMID: 36053093
Hypoplastic left heart syndrome (HLHS) is a relatively rare severe congenital heart defect (CHD) closely linked to other left ventricular outflow tract (LVOT) lesions including bicuspid aortic valve (BAV), one...
10.
Karunakaran K, Gabriel G, Balakrishnan N, Lo C, Ganapathiraju M
Genes (Basel)
. 2022 Apr;
13(4).
PMID: 35456433
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) affecting 1 in 5000 newborns. We constructed the interactome of 74 HLHS-associated genes identified from a large-scale mouse...