Geoffrey W Osborne
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Explore the profile of Geoffrey W Osborne including associated specialties, affiliations and a list of published articles.
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19
Citations
359
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Recent Articles
1.
Robson J, Remke M, Kool M, Julian E, Korshunov A, Pfister S, et al.
PLoS One
. 2019 Jan;
14(1):e0210665.
PMID: 30657775
High morbidity and mortality are common traits of malignant tumours and identification of the cells responsible is a focus of on-going research. Many studies are now reporting the use of...
2.
Fontaine F, Goodall S, Prokop J, Howard C, Moustaqil M, Kumble S, et al.
MAbs
. 2018 Apr;
10(4):596-606.
PMID: 29648920
Antibodies are routinely used to study the activity of transcription factors, using various in vitro and in vivo approaches such as electrophoretic mobility shift assay, enzyme-linked immunosorbent assay, genome-wide method...
3.
Jones M, Alfaleh M, Kumble S, Zhang S, Osborne G, Yeh M, et al.
Sci Rep
. 2016 May;
6:26240.
PMID: 27189586
A critical factor in the successful isolation of new antibodies by phage display is the presentation of a correctly folded antigen. While this is relatively simple for soluble proteins which...
4.
Jhaveri D, OKeeffe I, Robinson G, Zhao Q, Zhang Z, Nink V, et al.
J Neurosci
. 2015 May;
35(21):8132-44.
PMID: 26019330
The activity of neural precursor cells in the adult hippocampus is regulated by various stimuli; however, whether these stimuli regulate the same or different precursor populations remains unknown. Here, we...
5.
Osborne G, Andersen S, Battye F
Cytometry A
. 2015 May;
87(11):1047-51.
PMID: 25944021
Flow cytometry based electrostatic cell sorting is an important tool in the separation of cell populations. Existing instruments can sort single cells into multi-well collection plates, and keep track of...
6.
Sester D, Thygesen S, Sagulenko V, Vajjhala P, Cridland J, Vitak N, et al.
J Immunol
. 2014 Nov;
194(1):455-62.
PMID: 25404358
Inflammasomes are large protein complexes induced by a wide range of microbial, stress, and environmental stimuli that function to induce cell death and inflammatory cytokine processing. Formation of an inflammasome...
7.
Brunck M, Andersen S, Timmins N, Osborne G, Nielsen L
Cytometry A
. 2014 Jul;
85(12):1057-64.
PMID: 24995861
Absolute neutrophil count (ANC) is used clinically to monitor physiological dysfunctions such as myelosuppression or infection. In the research laboratory, ANC is a valuable measure to monitor the evolution of...
8.
Day B, Stringer B, Wilson J, Jeffree R, Jamieson P, Ensbey K, et al.
Cancers (Basel)
. 2013 Nov;
5(2):357-71.
PMID: 24216981
Brain cancer research has been hampered by a paucity of viable clinical tissue of sufficient quality and quantity for experimental research. This has driven researchers to rely heavily on long...
9.
Osborne G
Methods Mol Biol
. 2013 Aug;
1059:135-44.
PMID: 23934840
Flow cytometry is an advanced group of techniques for counting and quantifying microscopic particles such as cells, chromosomes, or functionalized beads. These approaches employ sophisticated optical and fluidic components to...
10.
Vukovic J, Bedin A, Bartlett P, Osborne G
Stem Cells Dev
. 2013 Mar;
22(16):2341-5.
PMID: 23517283
Neurogenesis occurs continuously in two brain regions of adult mammals, underpinned by a pool of resident neural stem cells (NSCs) that can differentiate into all neural cell types. To advance...