Geoffrey Schoenbaum
Overview
Explore the profile of Geoffrey Schoenbaum including associated specialties, affiliations and a list of published articles.
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180
Citations
9094
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Recent Articles
1.
Madangopal R, Zhao Y, Heins C, Zhou J, Liang B, Barbera G, et al.
bioRxiv
. 2025 Mar;
PMID: 40060503
Learning when to initiate or withhold actions is essential for survival and requires integration of past experiences with new information to adapt to changing environments. While stable prelimbic cortex (PL)...
2.
Costa K, Zhang Z, Deutsch D, Zhuo Y, Li G, Li Y, et al.
Curr Biol
. 2025 Mar;
PMID: 40037349
Dopamine release in the nucleus accumbens (NAcc) changes quickly in response to errors in predicting events like reward delivery but also slowly ramps up when animals are moving toward a...
3.
Zhang Z, Costa K, Langdon A, Schoenbaum G
Trends Cogn Sci
. 2025 Feb;
PMID: 40016003
Over recent decades, temporal difference reinforcement learning (TDRL) models have successfully explained much dopamine (DA) activity. This success has invited heightened scrutiny of late, with many studies challenging the validity...
4.
Zhang Z, Costa K, Zhuo Y, Li G, Li Y, Schoenbaum G
bioRxiv
. 2025 Jan;
PMID: 39829875
Learning in dynamic environments requires animals to not only associate cues with outcomes but also to determine cue salience, which modulates how quickly related associations are updated. While dopamine (DA)...
5.
Esber G, Esber G, Schoenbaum G, Iordanova M
Neurobiol Learn Mem
. 2025 Jan;
217:108021.
PMID: 39805526
No abstract available.
6.
The curious case of dopaminergic prediction errors and learning associative information beyond value
Kahnt T, Schoenbaum G
Nat Rev Neurosci
. 2025 Jan;
26(3):169-178.
PMID: 39779974
Transient changes in the firing of midbrain dopamine neurons have been closely tied to the unidimensional value-based prediction error contained in temporal difference reinforcement learning models. However, whereas an abundance...
7.
Takahashi Y, Zhang Z, Kahnt T, Schoenbaum G
bioRxiv
. 2025 Jan;
PMID: 39763911
Adaptive behavior depends on the ability to predict specific events, particularly those related to rewards. Armed with such associative information, we can infer the current value of predicted rewards based...
8.
Lehmann C, Miller N, Nair V, Costa K, Schoenbaum G, Moussawi K
Nat Commun
. 2025 Jan;
16(1):321.
PMID: 39747036
Cue reactivity is the maladaptive neurobiological and behavioral response upon exposure to drug cues and is a major driver of relapse. A widely accepted assumption is that drugs of abuse...
9.
Mueller L, Konya C, Sharpe M, Wikenheiser A, Schoenbaum G
Curr Biol
. 2024 Oct;
34(22):5223-5238.e3.
PMID: 39454572
Maladaptive decision-making is a hallmark of substance use disorders (SUDs), though how drugs of abuse alter neural representations supporting adaptive behavior remains poorly understood. Past studies show that the orbitofrontal...
10.
Zhang Z, Takahashi Y, Montesinos-Cartegena M, Kahnt T, Langdon A, Schoenbaum G
Nat Commun
. 2024 Oct;
15(1):8911.
PMID: 39414794
The orbitofrontal cortex (OFC) and hippocampus (HC) both contribute to the cognitive maps that support flexible behavior. Previously, we used the dopamine neurons to measure the functional role of OFC....