Geoffrey C Li
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Explore the profile of Geoffrey C Li including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
67
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Recent Articles
1.
Li G, Castro M, Ukwaththage T, Sanders C
J Struct Biol X
. 2024 Jun;
9:100100.
PMID: 38883400
NMR spectroscopy has played a pivotal role in fragment-based drug discovery by coupling detection of weak ligand-target binding with structural mapping of the binding site. Fragment-based screening by NMR has...
2.
Stefanski K, Li G, Marinko J, Carter B, Samuels D, Sanders C
J Biol Chem
. 2023 Sep;
299(10):105181.
PMID: 37716137
No abstract available.
3.
Stefanski K, Li G, Marinko J, Carter B, Samuels D, Sanders C
J Biol Chem
. 2022 Dec;
299(2):102839.
PMID: 36581210
Data from gnomAD indicate that a missense mutation encoding the T118M variation in human peripheral myelin protein 22 (PMP22) is found in roughly one of every 75 genomes of western...
4.
Olivieri C, Li G, Wang Y, V S M, Walker C, Kim J, et al.
Sci Adv
. 2022 Jul;
8(30):eabo0696.
PMID: 35905186
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation. A problem...
5.
Fantin S, Parson K, Yadav P, Juliano B, Li G, Sanders C, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33893233
Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma membrane destination...
6.
Olivieri C, Wang Y, Li G, V S M, Kim J, Stultz B, et al.
Elife
. 2020 Apr;
9.
PMID: 32338601
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP...
7.
Li G, Forster-Benson E, Sanders C
Biochim Biophys Acta Biomembr
. 2019 Sep;
1862(1):183058.
PMID: 31494120
Recent advances in whole genome and exome sequencing have dramatically increased the database of human gene variations. There are now enough sequenced human exomes and genomes to begin to identify...
8.
Hutchison J, Lu Z, Li G, Travis B, Mittal R, Deatherage C, et al.
Biochemistry
. 2017 Oct;
56(41):5481-5484.
PMID: 28980804
There remains a need for new non-ionic detergents that are suitable for use in biochemical and biophysical studies of membrane proteins. Here we explore the properties of n-dodecyl-β-melibioside (β-DDMB) micelles...
9.
Li G, Srivastava A, Kim J, Taylor S, Veglia G
Biochemistry
. 2015 Jun;
54(26):4042-9.
PMID: 26030372
Protein kinase A is a prototypical phosphoryl transferase, sharing its catalytic core (PKA-C) with the entire kinase family. PKA-C substrate recognition, active site organization, and product release depend on the...