Geoffrey C Farrell
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Explore the profile of Geoffrey C Farrell including associated specialties, affiliations and a list of published articles.
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129
Citations
7774
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Recent Articles
1.
Wang D, Phu A, McKee K, Strasser S, Sheils S, Weltman M, et al.
Open Forum Infect Dis
. 2024 Apr;
11(4):ofae155.
PMID: 38651137
Background: Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct-acting antiviral (DAA) therapy. However, a potential barrier to HCV elimination is the emergence of resistance-associated substitutions (RASs)...
2.
Horn C, Morales A, Savard C, Farrell G, Ioannou G
Hepatol Commun
. 2021 Sep;
6(1):12-35.
PMID: 34558856
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic...
3.
Singh S, Anirvan P, Reddy K, Conjeevaram H, Marchesini G, Rinella M, et al.
J Hepatol
. 2020 Dec;
74(4):972-974.
PMID: 33340575
No abstract available.
4.
Arfianti A, Pok S, Barn V, Haigh W, Yeh M, Ioannou G, et al.
J Hepatol
. 2020 Apr;
73(1):140-148.
PMID: 32302728
Background & Aims: Obesity and type 2 diabetes increase hepatocellular carcinoma (HCC) incidence in humans and accelerate diethylnitrosamine (DEN)-induced hepatocarcinogenesis in mice. We investigated whether exercise reduces HCC development in...
5.
Ioannou G, Landis C, Jin G, Haigh W, Farrell G, Kuver R, et al.
Hepatol Commun
. 2019 Jun;
3(6):776-791.
PMID: 31168512
It is unclear what drives the development of fibrosing nonalcoholic steatohepatitis (NASH). We aimed to determine whether cholesterol crystallization within hepatocyte lipid droplets (LDs) distinguishes patients with fibrosing NASH from...
6.
Farrell G, Wardell R, Teoh N, Chitturi S
Intern Med J
. 2019 May;
49(5):681-683.
PMID: 31083812
No abstract available.
7.
Arfianti E, Larter C, Lee S, Barn V, Haigh G, Yeh M, et al.
J Clin Transl Res
. 2019 Mar;
2(1):26-37.
PMID: 30873458
Background: There are strong links between obesity, diabetes and hepatocellular carcinoma (HCC), but molecular mechanisms remain unclear. Aim: We tested the proposed involvement of NF-κB, IL-6/STAT3 and Akt/mTORC1 before onset...
8.
de Haan L, van der Lely S, Warps A, Hofsink Q, Olthof P, de Keijzer M, et al.
J Clin Transl Res
. 2019 Feb;
4(1):1-46.
PMID: 30761355
Background: Liver regeneration following partial hepatectomy (PHx) is a complicated process involving multiple organs and several types of signaling networks. The bile acid-activated metabolic pathways occupy an auxiliary yet important...
9.
van Golen R, Reiniers M, Marsman G, Alles L, Van Rooyen D, Petri B, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 Jan;
1865(6):1192-1200.
PMID: 30658161
Objective And Background: Activation of sterile inflammation after hepatic ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with mitochondrial oxidative stress and cell death during early...
10.
Poekes L, Gillard J, Farrell G, Horsmans Y, Leclercq I
Lab Invest
. 2018 Sep;
99(1):4-16.
PMID: 30258096
Nonalcoholic steatohepatitis (NASH) is the form of nonalcoholic fatty liver disease that can evolve into cirrhosis. Lifestyle modifications achieving 10% weight loss reverse NASH, but there are no effective approved...