Geoff S Higgins
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Explore the profile of Geoff S Higgins including associated specialties, affiliations and a list of published articles.
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51
Citations
1796
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Recent Articles
1.
Low J, Rodriguez-Berriguete G, Higgins G
BMJ Oncol
. 2025 Jan;
3(1):e000192.
PMID: 39886153
Repurposing established non-cancer drugs for the treatment of cancer offers potential benefits such as speed of clinical translation and financial efficiencies. In this study, we assess the landscape of repurposing...
2.
McAteer M, McGowan D, Cook G, Leung H, Ng T, OConnor J, et al.
BMC Med
. 2025 Jan;
23(1):37.
PMID: 39849494
Background: The clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established...
3.
OConnor J, Tessyman V, Little R, Babur M, Forster D, Latif A, et al.
Cancer Res Commun
. 2024 Sep;
4(10):2565-2574.
PMID: 39240065
Oxygen-enhanced MRI (OE-MRI) has shown promise for quantifying and spatially mapping tumor hypoxia, either alone or in combination with perfusion imaging. Previous studies have validated the technique in mouse models...
4.
Haas R, Frame G, Khan S, Neilsen B, Hong B, Yeo C, et al.
Cancer Res Commun
. 2024 Aug;
4(9):2463-2479.
PMID: 39166898
Significance: Radiation is standard of care in prostate cancer. Yet, we have little understanding of its failure. We demonstrate a new paradigm that radioresistance is fractionation specific and identified POLQ...
5.
Cook E, Su K, Higgins G, Johnsen R, Bouhnik J, McGowan D
EJNMMI Phys
. 2024 May;
11(1):42.
PMID: 38691232
Background: Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for attenuation correction of the images....
6.
Rodriguez-Berriguete G, Puliyadi R, Machado N, Barberis A, Prevo R, McLaughlin M, et al.
Cell Death Dis
. 2024 Jan;
15(1):32.
PMID: 38212297
Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer cells. However, a substantial number of patients treated with...
7.
Machado N, Heather L, Harris A, Higgins G
Br J Cancer
. 2023 Aug;
129(6):897-899.
PMID: 37563220
No abstract available.
8.
Stockley M, Benedetti G, Blencowe P, Boulton S, Boyd S, Calder M, et al.
J Med Chem
. 2023 Feb;
PMID: 36815444
No abstract available.
9.
Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland H, et al.
Clin Cancer Res
. 2023 Jan;
29(8):1631-1642.
PMID: 36689546
Purpose: DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but...
10.
Bourigault P, Skwarski M, Macpherson R, Higgins G, McGowan D
Sci Rep
. 2022 Dec;
12(1):21746.
PMID: 36526815
Positron emission tomography (PET)/computed tomography (CT) using the radiotracer 18F-Fluoromisonidazole (FMISO) has been widely employed to image tumour hypoxia and is of interest to help develop novel hypoxia modifiers and...