Geeske M van Woerden
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Explore the profile of Geeske M van Woerden including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Hernandes V, Heuvelmans A, Gualtieri V, Meijer D, van Woerden G, Greplova E
Front Neurosci
. 2024 Dec;
18:1446578.
PMID: 39703343
Neuronal activity in the highly organized networks of the central nervous system is the vital basis for various functional processes, such as perception, motor control, and cognition. Understanding interneuronal connectivity...
2.
Gauger S, Lie M, Wallaard I, Tian Y, Marek A, Frolund B, et al.
Basic Clin Pharmacol Toxicol
. 2024 Dec;
136(1):e14112.
PMID: 39668309
Angelman Syndrome (AS) is a neurodevelopmental disorder caused by the loss of function of ubiquitin-protein ligase E3A (UBE3A), resulting in marked changes in synaptic plasticity. In AS mice, a dysregulation...
3.
Cheung J, van Woerden G, Veenma D
Curr Opin Neurobiol
. 2024 Dec;
90:102935.
PMID: 39631163
Neurodevelopmental disorders are a heterogenous group of brain disorders impacting cognitive, adaptive, motor, and speech language development. With advancements in diagnostics an increasing number of causative genes are discovered, including...
4.
Heuvelmans A, Proietti Onori M, Frega M, de Hoogen J, Nel E, Elgersma Y, et al.
Exp Neurol
. 2024 Jun;
379:114874.
PMID: 38914275
The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is a ubiquitous cellular pathway. mTORopathies, a group of disorders characterized by hyperactivity of the mTORC1 pathway, illustrate the prominent...
5.
van Houtum L, Baare W, Beckmann C, Castro-Fornieles J, Cecil C, Dittrich J, et al.
Eur Child Adolesc Psychiatry
. 2024 Apr;
33(11):3885-3898.
PMID: 38613677
Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission of risk for mental illness in one's children is...
6.
Rigter P, de Konink C, Dunn M, Proietti Onori M, Humberson J, Thomas M, et al.
Am J Hum Genet
. 2024 Jan;
111(2):364-382.
PMID: 38272033
The calcium/calmodulin-dependent protein kinase type 2 (CAMK2) family consists of four different isozymes, encoded by four different genes-CAMK2A, CAMK2B, CAMK2G, and CAMK2D-of which the first three have been associated recently...
7.
Ebstein F, Kury S, Most V, Rosenfelt C, Scott-Boyer M, van Woerden G, et al.
Sci Transl Med
. 2023 May;
15(698):eabo3189.
PMID: 37256937
A critical step in preserving protein homeostasis is the recognition, binding, unfolding, and translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase-associated with various cellular activities) termed PSMC1-6, which...
8.
Rigter P, de Konink C, van Woerden G
Front Neurosci
. 2023 Jan;
16:1086994.
PMID: 36685241
Introduction: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and...
9.
Rigter P, Wallaard I, Aghadavoud Jolfaei M, Kingma J, Post L, Elgersma M, et al.
iScience
. 2022 Oct;
25(11):105303.
PMID: 36304100
With the recent findings that mutations in the gene encoding the α-subunit of calcium/calmodulin-dependent protein kinase II (CAMK2A) causes a neurodevelopmental disorder (NDD), it is of great therapeutic relevance to...
10.
Palmelund L, van Woerden G, Brauner-Osborne H, Wellendorph P
J Pharmacol Toxicol Methods
. 2022 Sep;
118:107226.
PMID: 36174932
Ca/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a multifunctional Ser/Thr kinase involved in several neuronal signaling pathways including synaptic plasticity. CaMKIIα autonomous activity is highly dependent on Thr286 autophosphorylation (pThr286),...