Geert-Jan Biessels
Overview
Explore the profile of Geert-Jan Biessels including associated specialties, affiliations and a list of published articles.
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21
Citations
500
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Recent Articles
1.
Trieu C, Van Harten A, Leeuwis A, Exalto L, Hooghiemstra A, Verberk I, et al.
J Alzheimers Dis
. 2024 Mar;
98(3):987-1000.
PMID: 38489178
Background: We hypothesize that Alzheimer's disease (AD)-related pathology may accelerate cognitive decline in patients with cardiovascular diseases. Objective: To investigate the association between blood-based biomarkers of AD, astrocyte activation, and...
2.
van Dinther M, Hooghiemstra A, Bron E, Versteeg A, Leeuwis A, Kalay T, et al.
Alzheimers Dement
. 2023 Jul;
20(1):136-144.
PMID: 37491840
Introduction: Chronic cerebral hypoperfusion is one of the assumed pathophysiological mechanisms underlying vascular cognitive impairment (VCI). We investigated the association between baseline cerebral blood flow (CBF) and cognitive decline after...
3.
De Luca A, Kuijf H, Exalto L, Thiebaut de Schotten M, Biessels G
Brain Struct Funct
. 2022 Aug;
227(7):2553-2567.
PMID: 35994115
In cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized prediction. Here, we investigate whether considering abnormalities in brain tracts...
4.
De Luca A, Karayumak S, Leemans A, Rathi Y, Swinnen S, Gooijers J, et al.
Neuroimage
. 2022 Jul;
259:119439.
PMID: 35788044
Quantification methods based on the acquisition of diffusion magnetic resonance imaging (dMRI) with multiple diffusion weightings (e.g., multi-shell) are becoming increasingly applied to study the in-vivo brain. Compared to single-shell...
5.
De Luca A, Ianus A, Leemans A, Palombo M, Shemesh N, Zhang H, et al.
Neuroimage
. 2021 Jul;
240:118367.
PMID: 34237442
Diffusion MRI (dMRI) has become an invaluable tool to assess the microstructural organization of brain tissue. Depending on the specific acquisition settings, the dMRI signal encodes specific properties of the...
6.
Leeuwis A, Hooghiemstra A, Bron E, Kuipers S, Oudeman E, Kalay T, et al.
Alzheimers Dement (N Y)
. 2020 Sep;
6(1):e12034.
PMID: 32995468
Introduction: We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure...
7.
Carmichael O, Stuchlik P, Pillai S, Biessels G, Dhullipudi R, Madden-Rusnak A, et al.
J Clin Endocrinol Metab
. 2019 May;
104(10):4492-4500.
PMID: 31058974
Context: It is unclear how adolescent glycemic status relates to brain health in adulthood. Objective: To assess the association between adolescent fasting plasma glucose (FPG) and MRI-based brain measures in...
8.
Janssen J, Koekkoek P, Biessels G, Kappelle J, Rutten G
BMJ Open
. 2019 Feb;
9(1):e024696.
PMID: 30782740
Objectives: To assess changes in depressive symptoms and health-related quality of life (HRQOL) after screening for cognitive impairment in people with type 2 diabetes. Design: A prospective cohort study, part...
9.
Verwer J, Biessels G, Heinen R, Exalto L, Emmelot-Vonk M, Koek H
Alzheimer Dis Assoc Disord
. 2017 Dec;
32(3):214-219.
PMID: 29240562
Cerebral small vessel disease (CSVD) occurs often in memory clinic patients. Apart from cognitive deficits, these patients can express physical decline, which predicts adverse health outcomes. In this study, we...
10.
Ryan N, Biessels G, Kim L, Nicholas J, Barber P, Walsh P, et al.
Neurobiol Aging
. 2015 Sep;
36(12):3140-3151.
PMID: 26410308
Familial Alzheimer's disease (FAD) treatment trials raise interest in the variable occurrence of cerebral amyloid angiopathy (CAA); an emerging important factor in amyloid-modifying therapy. Previous pathological studies reported particularly severe...