Host Entry Factors of Rift Valley Fever Virus Infection

Overview

Journal Adv Virus Res

Specialty Microbiology

Date 2023 Oct 13

PMID 37832991

Authors

Safder S Ganaie

Daisy W Leung

Amy L Hartman

Gaya K Amarasinghe

Affiliations

Soon will be listed here.

Abstract

Rift Valley Fever Virus (RVFV) is a negative sense segmented RNA virus that can cause severe hemorrhagic fever. The tri-segmented virus genome encodes for six (6) multifunctional proteins that engage host factors at a variety of different stages in the replication cycle. The S segment encodes nucleoprotein (N) and nonstructural protein S (NSs), the M segment encodes viral glycoproteins Gn and Gc as well as nonstructural protein M (NSm) and the L segment encodes the viral polymerase (L). Viral glycoproteins Gn and Gc are responsible for entry by binding to a number of host factors. Our recent studies identified a scavenger receptor, LDL receptor related protein 1 (Lrp1), as a potential pro-viral host factor for RVFV and related viruses, including Oropouche virus (OROV) infection. Coincidentally, several recent studies identified other LDL family proteins as viral entry factors and receptors for other viral families. Collectively, these observations suggest that highly conserved LDL family proteins may play a significant role in facilitating entry of viruses from several distinct families. Given the significant roles of viral and host factors during infection, characterization of these interactions is critical for therapeutic targeting with neutralizing antibodies and vaccines.

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References

Lopez N, Muller R, Prehaud C, Bouloy M . The L protein of Rift Valley fever virus can rescue viral ribonucleoproteins and transcribe synthetic genome-like RNA molecules. J Virol. 1995; 69(7):3972-9. PMC: 189128. DOI: 10.1128/JVI.69.7.3972-3979.1995. View

Caminade C, Ndione J, Diallo M, MacLeod D, Faye O, Ba Y . Rift Valley Fever outbreaks in Mauritania and related environmental conditions. Int J Environ Res Public Health. 2014; 11(1):903-18. PMC: 3924481. DOI: 10.3390/ijerph110100903. View

Kalveram B, Lihoradova O, Ikegami T . NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. J Virol. 2011; 85(13):6234-43. PMC: 3126510. DOI: 10.1128/JVI.02255-10. View

Le May N, Dubaele S, Proietti De Santis L, Billecocq A, Bouloy M, Egly J . TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Cell. 2004; 116(4):541-50. DOI: 10.1016/s0092-8674(04)00132-1. View

ELLIS D, Simpson D, Stamford S, Abdel Wahab K . Rift Valley fever virus: some ultrastructural observations on material from the outbreak in Egypt 1977. J Gen Virol. 1979; 42(2):329-37. DOI: 10.1099/0022-1317-42-2-329. View

Hartman A, Powell D, Bethel L, Caroline A, Schmid R, Oury T . Aerosolized rift valley fever virus causes fatal encephalitis in african green monkeys and common marmosets. J Virol. 2013; 88(4):2235-45. PMC: 3911574. DOI: 10.1128/JVI.02341-13. View

de Boer S, Kortekaas J, Spel L, Rottier P, Moormann R, Bosch B . Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion protein. J Virol. 2012; 86(24):13642-52. PMC: 3503025. DOI: 10.1128/JVI.01973-12. View

Scharton D, Van Wettere A, Bailey K, Vest Z, Westover J, Siddharthan V . Rift Valley fever virus infection in golden Syrian hamsters. PLoS One. 2015; 10(1):e0116722. PMC: 4301868. DOI: 10.1371/journal.pone.0116722. View

Phoenix I, Nishiyama S, Lokugamage N, Hill T, Huante M, Slack O . N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN. Viruses. 2016; 8(5). PMC: 4885104. DOI: 10.3390/v8050149. View

10.

Clark L, Clark S, Lin C, Liu J, Coscia A, Nabel K . VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2021; 602(7897):475-480. PMC: 8808280. DOI: 10.1038/s41586-021-04326-0. View

11.

Bouloy M, Weber F . Molecular biology of rift valley Fever virus. Open Virol J. 2010; 4:8-14. PMC: 2878978. DOI: 10.2174/1874357901004020008. View

12.

Fontenille D, Traore-Lamizana M, Diallo M, Thonnon J, Digoutte J, Zeller H . New vectors of Rift Valley fever in West Africa. Emerg Infect Dis. 1998; 4(2):289-93. PMC: 2640145. DOI: 10.3201/eid0402.980218. View

13.

Hofmann H, Li X, Zhang X, Liu W, Kuhl A, Kaup F . Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines. J Virol. 2013; 87(8):4384-94. PMC: 3624395. DOI: 10.1128/JVI.02628-12. View

14.

McIntosh B, Russell D, Dos Santos I, Gear J . Rift Valley fever in humans in South Africa. S Afr Med J. 1980; 58(20):803-6. View

15.

de Boer S, Kortekaas J, de Haan C, Rottier P, Moormann R, Bosch B . Heparan sulfate facilitates Rift Valley fever virus entry into the cell. J Virol. 2012; 86(24):13767-71. PMC: 3503077. DOI: 10.1128/JVI.01364-12. View

16.

Ikegami T, Makino S . The pathogenesis of Rift Valley fever. Viruses. 2011; 3(5):493-519. PMC: 3111045. DOI: 10.3390/v3050493. View

17.

Zhang R, Kim A, Fox J, Nair S, Basore K, Klimstra W . Mxra8 is a receptor for multiple arthritogenic alphaviruses. Nature. 2018; 557(7706):570-574. PMC: 5970976. DOI: 10.1038/s41586-018-0121-3. View

18.

Balenghien T, Cardinale E, Chevalier V, Elissa N, Failloux A, Jean Jose Nipomichene T . Towards a better understanding of Rift Valley fever epidemiology in the south-west of the Indian Ocean. Vet Res. 2013; 44:78. PMC: 3848763. DOI: 10.1186/1297-9716-44-78. View

19.

Connors K, Hartman A . Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus. Annu Rev Virol. 2022; 9(1):437-450. PMC: 10316117. DOI: 10.1146/annurev-virology-091919-065806. View

20.

Terasaki K, Won S, Makino S . The C-terminal region of Rift Valley fever virus NSm protein targets the protein to the mitochondrial outer membrane and exerts antiapoptotic function. J Virol. 2012; 87(1):676-82. PMC: 3536385. DOI: 10.1128/JVI.02192-12. View