Gavin W G Wilkinson
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Explore the profile of Gavin W G Wilkinson including associated specialties, affiliations and a list of published articles.
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54
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Recent Articles
11.
Wilkinson G, Davison A, Tomasec P, Fielding C, Aicheler R, Murrell I, et al.
Med Microbiol Immunol
. 2015 Apr;
204(3):273-84.
PMID: 25894764
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently...
12.
Hsu J, Van den Boomen D, Tomasec P, Weekes M, Antrobus R, Stanton R, et al.
PLoS Pathog
. 2015 Apr;
11(4):e1004811.
PMID: 25875600
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I)....
13.
Stack G, Jones E, Marsden M, Stacey M, Snelgrove R, Lacaze P, et al.
PLoS Pathog
. 2015 Feb;
11(2):e1004641.
PMID: 25654642
CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However,...
14.
McSharry B, Forbes S, Avdic S, Randall R, Wilkinson G, Abendroth A, et al.
J Virol
. 2014 Nov;
89(2):1479-83.
PMID: 25392213
The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to...
15.
Stanton R, Prodhomme V, Purbhoo M, Moore M, Aicheler R, Heinzmann M, et al.
Cell Host Microbe
. 2014 Aug;
16(2):201-214.
PMID: 25121749
Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations. Among these, the deletion of the UL/b' domain is associated...
16.
Weekes M, Tomasec P, Huttlin E, Fielding C, Nusinow D, Stanton R, et al.
Cell
. 2014 Jun;
157(6):1460-1472.
PMID: 24906157
A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic...
17.
Raybould R, Fiander A, Wilkinson G, Hibbitts S
J Virol Methods
. 2014 Jun;
206:51-4.
PMID: 24880069
Human Papillomavirus (HPV) infection is the primary cause of cervical neoplasia. HPV DNA is integrated into the human genome in the majority of cervical cancers. The nature of integration may...
18.
Fielding C, Aicheler R, Stanton R, Wang E, Han S, Seirafian S, et al.
PLoS Pathog
. 2014 May;
10(5):e1004058.
PMID: 24787765
NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the...
19.
Stacey M, Marsden M, Pham N T, Clare S, Dolton G, Stack G, et al.
Cell Host Microbe
. 2014 Apr;
15(4):471-83.
PMID: 24721575
During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replication and pathology in multiple organs. This disseminated infection is ultimately controlled, but the underlying immune defense mechanisms are...
20.
Holcakova J, Muller P, Tomasec P, Hrstka R, Nekulova M, Krystof V, et al.
PLoS One
. 2014 Mar;
9(2):e89228.
PMID: 24586613
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and...