Gavin Rumbaugh
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Explore the profile of Gavin Rumbaugh including associated specialties, affiliations and a list of published articles.
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70
Citations
4018
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Recent Articles
11.
Radnai L, Surman M, Hafenbreidel M, Young E, Stremel R, Lin L, et al.
ACS Chem Biol
. 2021 Sep;
16(11):2164-2173.
PMID: 34558887
Myosin IIs, actin-based motors that utilize the chemical energy of adenosine 5'-triphosphate (ATP) to generate force, have potential as therapeutic targets. Their heavy chains differentiate the family into muscle (skeletal...
12.
Llamosas N, Michaelson S, Vaissiere T, Rojas C, Miller C, Rumbaugh G
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34404727
A significant proportion of autism risk genes regulate synapse function, including plasticity, which is believed to contribute to behavioral abnormalities. However, it remains unclear how impaired synapse plasticity contributes to...
13.
Radnai L, Stremel R, Vaissiere T, Lin L, Cameron M, Martin W, et al.
J Biol Methods
. 2020 Nov;
7(3):e136.
PMID: 33204739
Cytokinesis is the last step of mitotic cell division that separates the cytoplasm of dividing cells. Small molecule inhibitors targeting either the elements of the regulatory pathways controlling cytokinesis, or...
14.
Aten S, Kalidindi A, Yoon H, Rumbaugh G, Hoyt K, Obrietan K
Eur J Neurosci
. 2020 Nov;
53(3):732-749.
PMID: 33174316
The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master circadian clock. The phasing of the SCN oscillator is locked to the daily solar cycle, and an intracellular signaling...
15.
Llamosas N, Arora V, Vij R, Kilinc M, Bijoch L, Rojas C, et al.
J Neurosci
. 2020 Sep;
40(41):7980-7994.
PMID: 32887745
is a major genetic risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy. loss-of-function variants in this gene cause a neurodevelopmental disorder defined by cognitive impairment, social-communication...
16.
Chen J, Zhang P, Abe M, Aikawa H, Zhang L, Frank A, et al.
J Am Chem Soc
. 2020 May;
142(19):8706-8727.
PMID: 32364710
Approximately 95% of human genes are alternatively spliced, and aberrant splicing events can cause disease. One pre-mRNA that is alternatively spliced and linked to neurodegenerative diseases is tau (microtubule-associated protein...
17.
Gou G, Roca-Fernandez A, Kilinc M, Serrano E, Reig-Viader R, Araki Y, et al.
J Neurochem
. 2020 Feb;
154(6):618-634.
PMID: 32068252
The SynGAP protein is a major regulator of synapse biology and neural circuit function. Genetic variants linked to epilepsy and intellectual disability disrupt synaptic function and neural excitability. SynGAP has...
18.
Young E, Lin H, Kamenecka T, Rumbaugh G, Miller C
J Neurosci
. 2020 Feb;
40(13):2695-2707.
PMID: 32066582
Nonmuscle myosin II inhibition (NMIIi) in the basolateral amygdala (BLA), but not dorsal hippocampus (CA1), selectively disrupts memories associated with methamphetamine (METH) days after learning, without retrieval. However, the molecular...
19.
Gripp K, Schill L, Schoyer L, Stronach B, Bennett A, Blaser S, et al.
Am J Med Genet A
. 2019 Dec;
182(3):597-606.
PMID: 31825160
The RASopathies are a group of genetic disorders that result from germline pathogenic variants affecting RAS-mitogen activated protein kinase (MAPK) pathway genes. RASopathies share RAS/MAPK pathway dysregulation and share phenotypic...
20.
Radnai L, Stremel R, Sellers J, Rumbaugh G, Miller C
J Vis Exp
. 2019 Sep;
(150).
PMID: 31475972
ATPase enzymes utilize the free energy stored in adenosine triphosphate to catalyze a wide variety of endergonic biochemical processes in vivo that would not occur spontaneously. These proteins are crucial...