Gavin J Miller
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Explore the profile of Gavin J Miller including associated specialties, affiliations and a list of published articles.
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67
Citations
593
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Recent Articles
1.
Sunde-Brown P, Miller G, Houston T
J Org Chem
. 2025 Feb;
90(6):2288-2297.
PMID: 39909918
We report a practical 5 g scale stereoselective synthesis of the valuable iminosugar DMDP from d-fructose in only 7 synthetic steps and in a 70% overall yield, which doubles previously...
2.
OShea C, Miller G
Molecules
. 2024 Dec;
29(23).
PMID: 39683968
Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is a key regulator of biological processes. Owing to the inherent structural complexity of HS,...
3.
Benckendorff C, Sunde-Brown P, Ni Cheallaigh A, Miller G
J Org Chem
. 2024 Nov;
89(23):16977-16989.
PMID: 39572188
Nucleoside analogs have proven highly successful in many pharmaceutical intervention strategies, and continued exploration of next generation structural motifs is required. Herein we discuss recent advances toward the chemical synthesis...
4.
Evans S, Tizzard G, Field R, Miller G
Carbohydr Res
. 2024 Sep;
545:109275.
PMID: 39341003
Regio- and stereo-selective synthetic routes to 2-deoxy-2-fluoro-d-mannose building blocks are often experimentally challenging when using Selectfluor with the corresponding glycal. We targeted a late-stage method to introduce fluorine in a...
5.
Leslie K, Berry S, Miller G, Mahon C
J Am Chem Soc
. 2024 Sep;
146(40):27215-27232.
PMID: 39340450
Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools...
6.
Benzoylation of Tetrols: A Comparison of Regioselectivity Patterns for and Glycosides of d-Galactose
Porter J, Roberts J, Miller G
J Org Chem
. 2024 Sep;
89(19):14090-14097.
PMID: 39265180
Efficient protecting group strategies are important for glycan synthesis and represent a unique synthetic challenge in differentiating sugar ring hydroxyl groups. Direct methods to enable regioselective protecting group installation are...
7.
Dolan J, Ahmadipour S, Wahart A, Ni Cheallaigh A, Sari S, Eurtivong C, et al.
RSC Chem Biol
. 2024 Aug;
5(8):800-801.
PMID: 39092444
[This corrects the article DOI: 10.1039/D3CB00126A.].
8.
Wahart A, Beardmore L, Field R, Cosgrove S, Miller G
Org Lett
. 2024 Jul;
26(31):6642-6646.
PMID: 39075662
We explore biocatalytic aldehyde generation under aqueous conditions, concomitantly delivering access to a one-pot Wittig reaction using stabilized phosphoranes and granting diverse alkene products. Using a recombinant choline oxidase mutant,...
9.
Porter J, Noble A, Signoret N, Fascione M, Miller G
ACS Omega
. 2024 Jul;
9(29):31703-31713.
PMID: 39072123
Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer properties against a range of tumor types but is rapidly inactivated...
10.
Li Z, Di Vagno L, Chawla H, Ni Cheallaigh A, Critcher M, Sammon D, et al.
bioRxiv
. 2024 Jul;
PMID: 38979271
Mammalian cells orchestrate signalling through interaction events on their surfaces. Proteoglycans are an intricate part of these interactions, carrying large glycosaminoglycan polysaccharides that recruit signalling molecules. Despite their importance in...