Gavin A Huttley
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Explore the profile of Gavin A Huttley including associated specialties, affiliations and a list of published articles.
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36
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25878
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Recent Articles
1.
Zhu Y, Ong C, Huttley G
Genetics
. 2020 Mar;
215(1):25-40.
PMID: 32193188
There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples....
2.
Kaehler B, Bokulich N, McDonald D, Knight R, Caporaso J, Huttley G
Nat Commun
. 2019 Oct;
10(1):4643.
PMID: 31604942
Popular naive Bayes taxonomic classifiers for amplicon sequences assume that all species in the reference database are equally likely to be observed. We demonstrate that classification accuracy degrades linearly with...
3.
Bokulich N, Dillon M, Bolyen E, Kaehler B, Huttley G, Caporaso J
J Open Res Softw
. 2019 Sep;
3(30).
PMID: 31552137
q2-sample-classifier is a plugin for the QIIME 2 microbiome bioinformatics platform that facilitates access, reproducibility, and interpretation of supervised learning (SL) methods for a broad audience of non-bioinformatics specialists.
4.
Bolyen E, Rideout J, Dillon M, Bokulich N, Abnet C, Al-Ghalith G, et al.
Nat Biotechnol
. 2019 Aug;
37(9):1091.
PMID: 31399723
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Bolyen E, Rideout J, Dillon M, Bokulich N, Abnet C, Al-Ghalith G, et al.
Nat Biotechnol
. 2019 Jul;
37(8):852-857.
PMID: 31341288
No abstract available.
6.
Sutherland T, Sriskantha A, Rapson T, Kaehler B, Huttley G
PLoS One
. 2018 Sep;
13(9):e0203948.
PMID: 30240428
Many of the challenges we currently face as an advanced society have been solved in unique ways by biological systems. One such challenge is developing strategies to avoid microbial infection....
7.
Bokulich N, Kaehler B, Rideout J, Dillon M, Bolyen E, Knight R, et al.
Microbiome
. 2018 May;
6(1):90.
PMID: 29773078
Background: Taxonomic classification of marker-gene sequences is an important step in microbiome analysis. Results: We present q2-feature-classifier ( https://github.com/qiime2/q2-feature-classifier ), a QIIME 2 plugin containing several novel machine-learning and alignment-based...
8.
Kaehler B, Yap V, Huttley G
Genome Biol Evol
. 2017 Feb;
9(1):134-149.
PMID: 28175284
Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage-specific adaptations. Selective pressure is measured on a per-gene basis by comparing...
9.
Zhu Y, Neeman T, Yap V, Huttley G
Genetics
. 2016 Dec;
205(2):843-856.
PMID: 27974498
Mutation processes differ between types of point mutation, genomic locations, cells, and biological species. For some point mutations, specific neighboring bases are known to be mechanistically influential. Beyond these cases,...
10.
Padovan A, Patel H, Chuah A, Huttley G, Krause S, Degenhardt J, et al.
PLoS One
. 2015 May;
10(5):e0123226.
PMID: 25978451
Phenotypic mosaic trees offer an ideal system for studying differential gene expression. We have investigated two mosaic eucalypt trees from two closely related species (Eucalyptus melliodora and E. sideroxylon), which...