Gautham K Rao
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Explore the profile of Gautham K Rao including associated specialties, affiliations and a list of published articles.
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17
Citations
131
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Recent Articles
1.
Kwak-Kim J, Maier C, Villano C, Bowman C, Brennan F, Stanislaus D, et al.
J Reprod Immunol
. 2025 Feb;
169:104453.
PMID: 39999662
There have been remarkable advancements in understanding the complex and dynamic immune biological processes engaged during all stages of pregnancy. Exquisite control of immune processes is critical to successful outcome...
2.
Lopez J, Powles T, Braiteh F, Siu L, LoRusso P, Friedman C, et al.
Nat Med
. 2025 Jan;
31(1):152-164.
PMID: 39762422
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from...
3.
Hosseini I, Fleisher B, Getz J, Decalf J, Kwong M, Ovacik M, et al.
Pharmaceutics
. 2024 May;
16(5).
PMID: 38794321
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and...
4.
Collinge M, Neff-LaFord H, Akella S, Fogal B, Fraser K, Jabbour J, et al.
Regul Toxicol Pharmacol
. 2024 Apr;
150:105630.
PMID: 38642729
Immunotoxicology/immunosafety science is rapidly evolving, with novel modalities and immuno-oncology among the primary drivers of new tools and technologies. The Immunosafety Working Group of IQ/DruSafe sought to better understand some...
5.
Wu K, Adedeji A, Zabka T, Hosseini I, Kenkre R, Getz J, et al.
Toxicol Appl Pharmacol
. 2024 Jan;
483:116837.
PMID: 38278496
FLT3L-Fc is a cytokine-Fc fusion agonizing receptor-type tyrosine-protein kinase FLT3 (fms-related tyrosine kinase 3; CD135). FLT3 is expressed on dendritic cells (DCs) as well as myeloid and lymphoid progenitors. Nonclinical...
6.
Arjomandi A, Siradze K, Cheu M, Davancaze T, Yadav R, Rao G, et al.
AAPS J
. 2024 Jan;
26(1):16.
PMID: 38267613
Immunogenicity assessment is an essential part of biotherapeutic drug development. While the immune response in animals is not always representative of the human immune response, immunogenicity data obtained in animal...
7.
Rao G, Santagostino S, Wong L, Inoue A, Arjomandi A, Yadav R, et al.
Reprod Toxicol
. 2023 Dec;
123:108526.
PMID: 38141866
Zinpentraxin alfa is a recombinant human pentraxin-2 (PTX-2) developed for the treatment of various fibrotic diseases with the hypothesis that supplementing endogenous PTX-2 levels through intravenous administration should increase its...
8.
Ayalon G, Lee S, Adolfsson O, Foo-Atkins C, Atwal J, Blendstrup M, et al.
Sci Transl Med
. 2021 May;
13(593).
PMID: 33980574
Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate with disease course and severity better...
9.
Rao G, Prell R, Laing S, Burleson S, Nguyen A, McBride J, et al.
Toxicol Sci
. 2019 Feb;
169(2):409-421.
PMID: 30796434
A theoretical safety concern proposed in the influenza literature is that therapeutic antiviral antibodies could have the potential for antibody-dependent enhancement (ADE) of infection and disease. ADE may occur when...
10.
Rao G, Wong A, Collinge M, Sarhan J, Yarovinsky T, Ramgolam V, et al.
PLoS One
. 2018 Jul;
13(7):e0201103.
PMID: 30048492
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -stabilizing...