Gautam N Bijur
Overview
Explore the profile of Gautam N Bijur including associated specialties, affiliations and a list of published articles.
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15
Citations
811
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Recent Articles
1.
Gandy J, Melendez-Ferro M, Bijur G, Van Leuven F, Roche J, Lechat B, et al.
Synapse
. 2013 Feb;
67(6):313-27.
PMID: 23390016
Glycogen synthase kinase-3β (GSK3β) activity has been previously linked to Alzheimer's disease (AD) by its phosphorylation of tau and activation by amyloid. GSK3β intracellular distribution is important in regulating its...
2.
Li Y, Lu W, King T, Liu C, Bijur G, Bu G
PLoS One
. 2010 Jun;
5(6):e11014.
PMID: 20543981
Background: The low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling. Dickkopf 1 (Dkk1), a major secreted Wnt signaling antagonist, binds to LRP6 with high...
3.
Barksdale K, Perez-Costas E, Gandy J, Melendez-Ferro M, Roberts R, Bijur G
FASEB J
. 2010 May;
24(9):3590-9.
PMID: 20466876
Neuronal function in the brain requires energy in the form of ATP, and mitochondria are canonically associated with ATP production in neurons. The electrochemical gradient, which underlies the mitochondrial transmembrane...
4.
Perez-Costas E, Gandy J, Melendez-Ferro M, Roberts R, Bijur G
PLoS One
. 2010 Jan;
5(1):e8911.
PMID: 20111716
Glycogen synthase kinase-3beta (GSK3beta) is highly abundant in the brain. Various biochemical analyses have indicated that GSK3beta is localized to different intracellular compartments within brain cells. However, ultrastructural visualization of...
5.
Barksdale K, Bijur G
J Neurochem
. 2009 Feb;
108(5):1289-99.
PMID: 19187436
Akt is a known client protein of heat shock protein 90 (HSP90). We have found that HSP90 is responsible for Akt accumulation in the mitochondria in unstimulated cells. Treatment of...
6.
King T, Clodfelder-Miller B, Barksdale K, Bijur G
Neurotox Res
. 2008 Dec;
14(4):367-82.
PMID: 19073440
GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate...
7.
King T, Gandy J, Bijur G
Exp Cell Res
. 2006 Sep;
312(18):3693-700.
PMID: 16987514
The ubiquitously expressed protein glycogen synthase kinase-3 (GSK3) is constitutively active, however its activity is markedly diminished following phosphorylation of Ser21 of GSK3alpha and Ser9 of GSK3beta. Although several kinases...
8.
Gandy J, Rountree A, Bijur G
FEBS Lett
. 2006 May;
580(13):3051-8.
PMID: 16684529
The Ser/Thr kinase Akt1 is activated by growth factors subsequent to its phosphorylation on Thr308 and Ser473. In the present study, Akt1 was found to be constitutively modified with O-GlcNAc....
9.
De Sarno P, Bijur G, Zmijewska A, Li X, Jope R
Neurobiol Aging
. 2006 Feb;
27(3):413-22.
PMID: 16464655
Glycogen synthase kinase-3 (GSK3), which is inhibited by serine-phosphorylation, is involved in the neuropathology of Alzheimer's disease (AD). We tested if the two therapeutic strategies used for AD, inhibition of...
10.
Zhu W, Bijur G, Styles N, Li X
Brain Res Mol Brain Res
. 2004 Jun;
126(1):45-56.
PMID: 15207915
FOXO3a is a ubiquitously expressed mammalian forkhead transcription factor with a high expression level in adult brain. The activity of FOXO3a is inhibited by growth factors through activation of phosphatidylinositol...