Gary P Carlson
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Explore the profile of Gary P Carlson including associated specialties, affiliations and a list of published articles.
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34
Citations
143
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Recent Articles
1.
Cruzan G, Bus J, Andersen M, Carlson G, Banton M, Sarang S, et al.
Regul Toxicol Pharmacol
. 2018 Mar;
95:17-28.
PMID: 29496518
Based on 13 chronic studies, styrene exposure causes lung tumors in mice, but no tumor increases in other organs in mice or rats. Extensive research into the mode of action...
2.
Barchowsky A, Buckley L, Carlson G, Fitsanakis V, Ford S, Genter M, et al.
Toxicol Sci
. 2012 Mar;
127(2):331-8.
PMID: 22461448
Toxicology and careers in toxicology, as well as many other scientific disciplines, are undergoing rapid and dramatic changes as new discoveries, technologies, and hazards advance at a blinding rate. There...
3.
Carlson G
Toxicology
. 2012 Mar;
294(2-3):104-8.
PMID: 22386858
Styrene causes toxicity in both the lung and the liver. The study of the relationship of this toxicity to the metabolism of styrene has been aided by the use of...
4.
Carlson G
Drug Chem Toxicol
. 2011 Jul;
34(4):440-4.
PMID: 21749217
Styrene is known to be hepatotoxic and pneumotoxic in rodents, and these adverse effects are related to its metabolism. Mice deficient in the enzymes responsible for both the activation and...
5.
Carlson G
J Toxicol Environ Health A
. 2011 Jan;
74(6):347-50.
PMID: 21271435
Styrene is hepatotoxic and pneumotoxic in mice. Styrene oxide, the active metabolite, is detoxified via hydrolysis by microsomal epoxide hydrolase (mEH). Racemic styrene oxide was previously found to be more...
6.
Carlson G
J Toxicol Environ Health A
. 2010 Nov;
73(24):1689-99.
PMID: 21058172
Styrene, which is widely used in manufacturing, is both acutely and chronically toxic to mice. Styrene is metabolized by cytochromes P-450 to the toxic metabolite styrene oxide, which is detoxified...
7.
Carlson G
J Toxicol Environ Health A
. 2010 Apr;
73(11):766-72.
PMID: 20391119
Styrene is a widely used chemical, but it is known to produce lung and liver damage in mice. This may be related to oxidative stress associated with the decrease in...
8.
Harvilchuck J, Pu X, Klaunig J, Carlson G
Toxicology
. 2009 Aug;
264(3):171-8.
PMID: 19666080
In mice, styrene is hepatotoxic, pneumotoxic, and causes lung tumors. One explanation for the mechanism of toxicity is oxidative stress/damage. Previous studies have shown decreased glutathione levels, linked to increased...
9.
Harvilchuck J, Carlson G
Toxicology
. 2009 May;
259(3):149-52.
PMID: 19428955
Styrene exposure is highest among workers in the reinforced plastics industry with exposure seen for 5 consecutive days during the work week. Styrene is both hepatotoxic and pneumotoxic in mice,...
10.
Meszka-Jordan A, Mahlapuu R, Soomets U, Carlson G
J Toxicol Environ Health A
. 2009 Mar;
72(10):642-50.
PMID: 19308849
Styrene produces lung and liver damage that may be related to oxidative stress. The purpose of this study was to investigate the toxicity of (R)-styrene oxide (R-SO), the more active...