Gary Eitzen
Overview
Explore the profile of Gary Eitzen including associated specialties, affiliations and a list of published articles.
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31
Citations
647
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Recent Articles
1.
Shouib R, Eitzen G
Cell Signal
. 2024 Jul;
122:111321.
PMID: 39067837
Cytokine release from airway epithelial cells is a key immunological process that coordinates an immune response in the lungs. We propose that the Rho GTPase, Cdc42, regulates both transcription and...
2.
Zhang E, Van Petten J, Eitzen G
J Leukoc Biol
. 2024 Jun;
116(6):1498-1514.
PMID: 38943612
Mast cells are hematopoietic-derived immune cells that possess numerous cytoplasmic granules containing immune mediators such as cytokines and histamine. Antigen stimulation triggers mast cell granule exocytosis, releasing granule contents in...
3.
Ilarraza R, Chao D, Bodman J, Chesley A, Humble A, Shaheen F, et al.
J Leukoc Biol
. 2023 Apr;
114(2):116-125.
PMID: 37017007
A key molecule for neutrophil degranulation is Rac2 guanosine triphosphatase. Neutrophils from Rac2 knockout mice (Rac2-/-) exhibit impaired primary granule exocytosis in response to cytochalasin B/f-Met-Leu-Phe, while secondary and tertiary...
4.
Guo Y, Negre J, Eitzen G
Cells
. 2023 Feb;
12(4).
PMID: 36831204
When antigen-stimulated, mast cells release preformed inflammatory mediators stored in cytoplasmic granules. This occurs via a robust exocytosis mechanism termed degranulation. Our previous studies revealed that RhoA and Rac1 are...
5.
Shouib R, Eitzen G
Front Immunol
. 2023 Jan;
13:1069499.
PMID: 36618374
Airway epithelial cells can respond to incoming pathogens, allergens and stimulants through the secretion of cytokines and chemokines. These pro-inflammatory mediators activate inflammatory signaling cascades that allow a robust immune...
6.
Roczkowsky A, Doan M, Hlavay B, Mamik M, Branton W, McKenzie B, et al.
J Neurosci
. 2022 Aug;
42(37):7152-7165.
PMID: 35940876
Multiple sclerosis (MS) is a progressive and inflammatory demyelinating disease of the CNS. Peroxisomes perform critical functions that contribute to CNS homeostasis. We investigated peroxisome injury and mitigating effects of...
7.
Ibanga J, Zhang E, Eitzen G, Guo Y
PLoS One
. 2022 Mar;
17(3):e0265122.
PMID: 35316306
Mast cells are tissue-resident immune cells that have numerous cytoplasmic granules which contain preformed pro-inflammatory mediators. Upon antigen stimulation, sensitized mast cells undergo profound changes to their morphology and rapidly...
8.
Azad A, Farhan M, Murray C, Suzuki K, Eitzen G, Touret N, et al.
FASEB J
. 2021 Dec;
36(1):e22080.
PMID: 34882832
Angiogenesis is required in embryonic development and tissue repair in the adult. Vascular endothelial growth factor (VEGF) initiates angiogenesis, and VEGF or its receptor is targeted therapeutically to block pathological...
9.
Lu L, Raj S, Arizmendi N, Ding J, Eitzen G, Kwan P, et al.
Acta Biomater
. 2021 Sep;
136:159-169.
PMID: 34530142
Peptide based therapeutics are desirable owing to their high biological specificity. However, a number of these fail in clinical testing due to an adverse inflammatory response. Mast cells play a...
10.
Liu Y, Weaver C, Sen Y, Eitzen G, Simmonds A, Linchieh L, et al.
Front Cell Dev Biol
. 2021 Aug;
9:714710.
PMID: 34434934
Peroxisome biogenesis disorders (PBDs) are a group of metabolic developmental diseases caused by mutations in one or more genes encoding peroxisomal proteins. Zellweger syndrome spectrum (PBD-ZSS) results from metabolic dysfunction...