Gareth A Nye
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Explore the profile of Gareth A Nye including associated specialties, affiliations and a list of published articles.
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9
Citations
186
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Recent Articles
1.
Thoma A, Lyon M, Al-Shanti N, Nye G, Cooper R, Lightfoot A
Antioxidants (Basel)
. 2020 Aug;
9(8).
PMID: 32764412
Maladaptive endoplasmic reticulum (ER) stress is associated with modified reactive oxygen species (ROS) generation and mitochondrial abnormalities; and is postulated as a potential mechanism involved in muscle weakness in myositis,...
2.
Erlich A, Nye G, Brownbill P, Jensen O, Chernyavsky I
Interface Focus
. 2019 Sep;
9(5):20190021.
PMID: 31485311
The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood....
3.
Nye G, Ingram E, Johnstone E, Jensen O, Schneider H, Lewis R, et al.
J Physiol
. 2018 Jan;
596(23):5523-5534.
PMID: 29377190
The placenta is crucial for life. It is an ephemeral but complex organ acting as the barrier interface between maternal and fetal circulations, providing exchange of gases, nutrients, hormones, waste...
4.
Sakellariou G, McDonagh B, Porter H, Giakoumaki I, Earl K, Nye G, et al.
Antioxid Redox Signal
. 2017 Oct;
28(4):275-295.
PMID: 29065712
Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1) leads to accelerated age-related muscle loss and weakness, but specific deletion of CuZnSOD in skeletal muscle (mSod1KO mice) or...
5.
Nye G, Sakellariou G, Degens H, Lightfoot A
Clin Sci (Lond)
. 2017 Jul;
131(15):1919-1922.
PMID: 28687629
Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A...
6.
Sakellariou G, Pearson T, Lightfoot A, Nye G, Wells N, Giakoumaki I, et al.
Sci Rep
. 2016 Sep;
6:33944.
PMID: 27681159
Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role...
7.
Sakellariou G, Pearson T, Lightfoot A, Nye G, Wells N, Giakoumaki I, et al.
FASEB J
. 2016 Aug;
30(11):3771-3785.
PMID: 27550965
Age-related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and over. Considerable evidence indicates that oxidative damage and mitochondrial dysfunction...
8.
Lightfoot A, Sakellariou G, Nye G, McArdle F, Jackson M, Griffiths R, et al.
Redox Biol
. 2015 Aug;
6:253-259.
PMID: 26291279
TNF-α is a key inflammatory mediator and is proposed to induce transcriptional responses via the mitochondrial generation of Reactive Oxygen Species (ROS). The aim of this study was to determine...
9.
Lightfoot A, McCormick R, Nye G, McArdle A
Curr Opin Pharmacol
. 2014 Jun;
16:116-21.
PMID: 24880707
Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and...