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Gaohong She

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Zhu R, Chen H, Galanter J, She G, Cai F, Durk M, et al.
Clin Transl Sci . 2022 Feb; 15(5):1225-1237. PMID: 35157370
Several inflammatory cytokines that promote inflammation and pathogenesis in asthma signal through the Janus kinase 1 (JAK1) pathway. This phase I, randomized, placebo-controlled trial assessed the pharmacokinetics and safety of...
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Zhang W, Scalori A, Fuh F, McBride J, She G, Kierkus J, et al.
Inflamm Bowel Dis . 2021 Dec; 28(9):1348-1356. PMID: 34849918
Background: Etrolizumab, a humanized anti-β7 antibody, has not been studied in children. Here, we evaluate the pharmacokinetics, pharmacodynamics, and safety of etrolizumab in children with inflammatory bowel disease. Methods: Patients...
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Zhu R, Owen R, Wilkins J, Schoemaker R, Tian X, Gautier A, et al.
Pulm Pharmacol Ther . 2021 Sep; 71:102080. PMID: 34592476
The anti-immunoglobulin E (IgE) antibody, omalizumab (Xolair), is approved in the United States for the treatment of allergic asthma and chronic spontaneous urticaria, and has recently been studied for the...
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Deng R, She G, Maia M, Lim J, Peck M, McBride J, et al.
J Clin Pharmacol . 2020 Jul; 60(11):1509-1518. PMID: 32621543
MHAA4549A is a human anti-influenza A monoclonal antibody developed to treat influenza A. We report MHAA4549A serum, nasopharyngeal, and tracheal aspirate pharmacokinetics from a phase 2b study in hospitalized patients...
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Peck M, Rothenberg M, Deng R, Lewin-Koh N, She G, Kamath A, et al.
Antimicrob Agents Chemother . 2019 Mar; 63(6). PMID: 30910894
causes serious bacterial infections with high morbidity and mortality, necessitating the discovery of new antibiotics. DSTA4637S is a novel antibody-antibiotic conjugate designed to target intracellular that is not adequately eliminated...