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» Authors » Gail Benninghoff

Gail Benninghoff

Explore the profile of Gail Benninghoff including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 84
Followers 0
Related Specialties
Pharmacology
Chemistry
Top 10 Co-Authors
Gordon L Amidon
Marival Bermejo
Bart Hens
Yasuhiro Tsume
William L Hasler
Alex Yu
Joseph Dickens
Kerby Shedden
Paulo Paixao
Arjang Talattof
Published In
Mol Pharm
Int J Pharm
Eur J Pharm Sci
Eur J Pharm Biopharm
Affiliations
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Recent Articles
1.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State
Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, et al.
Mol Pharm . 2018 Nov; 15(12):5468-5478. PMID: 30417648
Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available to investigate the impact of GI physiology...
2.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions
Bermejo M, Paixao P, Hens B, Tsume Y, Koenigsknecht M, Baker J, et al.
Mol Pharm . 2018 Oct; 15(12):5454-5467. PMID: 30372084
The goal of this project was to explore and to statistically evaluate the responsible gastrointestinal (GI) factors that are significant factors in explaining the systemic exposure of ibuprofen, between and...
3.
Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project
Hens B, Sinko P, Job N, Dean M, Al-Gousous J, Salehi N, et al.
Int J Pharm . 2018 Jun; 548(1):120-127. PMID: 29944899
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in...
4.
Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach
Paixao P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, et al.
Eur J Pharm Biopharm . 2018 Jun; 129:162-174. PMID: 29857136
The goal of this study was to create a mass transport model (MTM) model for gastric emptying and upper gastrointestinal (GI) appearance that can capture the in vivo concentration-time profiles...
5.
Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach
Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, et al.
Eur J Pharm Sci . 2018 Jan; 115:258-269. PMID: 29378253
Supersaturating drug delivery systems (SDDS) have been put forward in the recent decades in order to circumvent the issue of low aqueous solubility. Prior to the start of clinical trials,...
6.
Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs
Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht M, Baker J, et al.
Mol Pharm . 2017 Jul; 14(12):4281-4294. PMID: 28737409
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time,...