Gaie Brown
Overview
Explore the profile of Gaie Brown including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
455
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Recent Articles
1.
Ravi L, Liang L, Wong P, Brown G, Tan B, Sugrue R
Antiviral Res
. 2013 Sep;
100(1):259-68.
PMID: 23994498
We have examined the role that hydroxymethylglutaryl coenzyme A reductase (HMGCR) plays during respiratory syncytial virus (RSV) maturation. Imaging analysis indicated that virus-induced changes in F-actin structure correlated with the...
2.
Oehler V, Filipe A, Montserret R, Costa D, Brown G, Penin F, et al.
J Virol
. 2012 May;
86(15):7818-28.
PMID: 22593157
The maturation of the hepatitis C virus (HCV) core protein requires proteolytic processing by two host proteases: signal peptidase (SP) and the intramembrane-cleaving protease signal peptide peptidase (SPP). Previous work...
3.
Radhakrishnan A, Yeo D, Brown G, Myaing M, Ravi Iyer L, Fleck R, et al.
Mol Cell Proteomics
. 2010 Jun;
9(9):1829-48.
PMID: 20530633
In this study, we used imaging and proteomics to identify the presence of virus-associated cellular proteins that may play a role in respiratory syncytial virus (RSV) maturation. Fluorescence microscopy of...
4.
Yeo D, Chan R, Brown G, Ying L, Sutejo R, Aitken J, et al.
Virology
. 2009 Jan;
386(1):168-82.
PMID: 19178924
We examined the structure of lipid-raft membranes in respiratory syncytial virus infected cells. Cholesterol depletion studies using methyl-beta-cyclodextrin suggested that membrane cholesterol was required for virus filament formation, but not...
5.
Jeffree C, Brown G, Aitken J, Su-Yin D, Tan B, Sugrue R
Virology
. 2007 Sep;
369(2):309-23.
PMID: 17825340
During respiratory syncytial virus (RSV) infection there is a close physical interaction between the filamentous actin (F-actin) and the virus, involving both inclusion bodies and the virus filaments. This interaction...
6.
Tan B, Brown G, Sugrue R
Methods Mol Biol
. 2007 May;
379:149-61.
PMID: 17502677
Sequences derived from the respiratory syncytial virus (RSV) fusion (F) protein were expressed in insect cells as recombinant glutathione-S-transferase (GST)-tagged proteins. The sequence covering the F2 subunit (GST-F2), and a...
7.
Functional analysis of the N-linked glycans within the fusion protein of respiratory syncytial virus
Li P, McL Rixon H, Brown G, Sugrue R
Methods Mol Biol
. 2007 May;
379:69-83.
PMID: 17502671
The respiratory syncytial virus fusion (F) protein is initially expressed as a single polypeptide chain (F0). The F0 subsequently undergoes posttranslational cleavage-by-cell protease activity to produce the F1 and F2...
8.
McDonald T, Jeffree C, Li P, McL Rixon H, Brown G, Aitken J, et al.
Virology
. 2006 Mar;
350(2):289-301.
PMID: 16513154
Glycan heterogeneity of the respiratory syncytial virus (RSV) fusion (F) protein was demonstrated by proteomics. The effect of maturation of the virus glycoproteins-associated glycans on virus infectivity was therefore examined...
9.
Brown G, McL Rixon H, Steel J, McDonald T, Pitt A, Graham S, et al.
Virology
. 2005 Jun;
338(1):69-80.
PMID: 15936795
In this report, the interaction between respiratory syncytial virus (RSV) and heat shock protein 70 (HSP70) was examined. Although no significant increase in total HSP70 protein levels was observed during...
10.
McDonald T, Pitt A, Brown G, McL Rixon H, Sugrue R
Virology
. 2004 Nov;
330(1):147-57.
PMID: 15527841
The interaction between the respiratory syncytial virus (RSV) polymerase complex and lipid rafts was examined in HEp2 cells. Lipid-raft membranes were prepared from virus-infected cells and their protein content was...