Gaia Pasqualetto
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Explore the profile of Gaia Pasqualetto including associated specialties, affiliations and a list of published articles.
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10
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44
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Recent Articles
1.
Pasqualetto G, Mack A, Lewis E, Cooper R, Holland A, Borucu U, et al.
PLoS One
. 2023 Jun;
18(6):e0287294.
PMID: 37347755
Hemocyanins are multimeric oxygen transport proteins present in the blood of arthropods and molluscs, containing up to 8 oxygen-binding functional units per monomer. In molluscs, hemocyanins are assembled in decamer...
2.
Pasqualetto G, Zuanon M, Brancale A, Young M
Front Pharmacol
. 2023 Feb;
14:1101023.
PMID: 36843952
P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular...
3.
Pasqualetto G, Zuanon M, Brancale A, Young M
Front Pharmacol
. 2023 Jan;
13:1094607.
PMID: 36712671
P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin....
4.
Picarazzi F, Zuanon M, Pasqualetto G, Cammarone S, Romeo I, Young M, et al.
J Chem Inf Model
. 2022 Nov;
62(22):5794-5805.
PMID: 36367985
N-terminal P23H opsin mutation accounts for most of retinitis pigmentosa (RP) cases. P23H functions and folding can be rescued by small chaperone ligands, which contributes to validate mutant opsin as...
5.
Pasqualetto G, Pileggi E, Schepelmann M, Varricchio C, Rozanowska M, Brancale A, et al.
Eur J Med Chem
. 2021 Sep;
226:113841.
PMID: 34555613
Inherited blinding diseases retinitis pigmentosa (RP) and a subset of Leber's congenital amaurosis (LCA) are caused by the misfolding and mistrafficking of rhodopsin molecules, which aggregate and accumulate in the...
6.
Pasqualetto G, Schepelmann M, Varricchio C, Pileggi E, Khogali C, Morgan S, et al.
Molecules
. 2020 Oct;
25(21).
PMID: 33114011
Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber's congenital amaurosis....
7.
Grimes L, Griffiths J, Pasqualetto G, Brancale A, Kemp P, Young M, et al.
Sci Rep
. 2020 May;
10(1):8292.
PMID: 32427920
The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to...
8.
Giancotti G, Rigo I, Pasqualetto G, Young M, Neyts J, Rocha-Pereira J, et al.
Sci Rep
. 2019 Dec;
9(1):18413.
PMID: 31804593
Human norovirus is the leading cause of acute gastroenteritis worldwide, affecting every year 685 million people. In about one third of cases, this virus affects children under five years of...
9.
Pasqualetto G, Brancale A, Young M
Front Pharmacol
. 2018 Feb;
9:58.
PMID: 29456508
P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP-their physiological ligand-is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X...
10.
Anthopoulos A, Pasqualetto G, Grimstead I, Brancale A
Faraday Discuss
. 2014 Oct;
169:323-42.
PMID: 25340878
In this paper, we describe a hybrid meta-heuristics method of energy minimization and conformational sampling and its application into our haptic-driven molecular modelling simulator. The proposed method has been designed...