Gabor Bunkoczi
Overview
Explore the profile of Gabor Bunkoczi including associated specialties, affiliations and a list of published articles.
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30
Citations
17543
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Recent Articles
1.
Li H, Yuan S, Minegishi Y, Suga A, Yoshitake K, Sheng X, et al.
Hum Mol Genet
. 2020 Jan;
29(3):444-458.
PMID: 31915829
Inherited optic neuropathies are rare eye diseases of optic nerve dysfunction that present in various genetic forms. Previously, mutation in three genes encoding mitochondrial proteins has been implicated in autosomal...
2.
Saur M, Hartshorn M, Dong J, Reeks J, Bunkoczi G, Jhoti H, et al.
Drug Discov Today
. 2019 Dec;
25(3):485-490.
PMID: 31877353
Recent advances in electron cryo-microscopy (cryo-EM) structure determination have pushed the resolutions obtainable by the method into the range widely considered to be of utility for drug discovery. Here, we...
3.
Liebschner D, Afonine P, Baker M, Bunkoczi G, Chen V, Croll T, et al.
Acta Crystallogr D Struct Biol
. 2019 Oct;
75(Pt 10):861-877.
PMID: 31588918
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop new therapeutics against diseases....
4.
Demydchuk M, Hill C, Zhou A, Bunkoczi G, Stein P, Marchesan D, et al.
Nat Commun
. 2017 Jun;
8:15786.
PMID: 28593992
Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and...
5.
Terwilliger T, Bunkoczi G, Hung L, Zwart P, Smith J, Akey D, et al.
Acta Crystallogr D Struct Biol
. 2016 Mar;
72(Pt 3):359-74.
PMID: 26960123
A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, algorithms and tools for evaluating and optimizing the useful anomalous...
6.
Terwilliger T, Bunkoczi G, Hung L, Zwart P, Smith J, Akey D, et al.
Acta Crystallogr D Struct Biol
. 2016 Mar;
72(Pt 3):346-58.
PMID: 26960122
A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. A simple theoretical framework for describing measurements of anomalous differences and...
7.
Bunkoczi G, Wallner B, Read R
Structure
. 2015 Jan;
23(2):397-406.
PMID: 25619999
Predicted structures submitted for CASP10 have been evaluated as molecular replacement models against the corresponding sets of structure factor amplitudes. It has been found that the log-likelihood gain score computed...
8.
Bunkoczi G, McCoy A, Echols N, Grosse-Kunstleve R, Adams P, Holton J, et al.
Nat Methods
. 2014 Dec;
12(2):127-30.
PMID: 25532136
We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD) X-ray analysis with weak...
9.
Zhao H, Sheng G, Wang J, Wang M, Bunkoczi G, Gong W, et al.
Nature
. 2014 Aug;
515(7525):147-50.
PMID: 25118175
Clustered regularly interspaced short palindromic repeats (CRISPR) together with CRISPR-associated (Cas) proteins form the CRISPR/Cas system to defend against foreign nucleic acids of bacterial and archaeal origin. In the I-E...
10.
Echols N, Moriarty N, Klei H, Afonine P, Bunkoczi G, Headd J, et al.
Acta Crystallogr D Biol Crystallogr
. 2014 Jan;
70(Pt 1):144-54.
PMID: 24419387
High-throughput drug-discovery and mechanistic studies often require the determination of multiple related crystal structures that only differ in the bound ligands, point mutations in the protein sequence and minor conformational...