G S Hughes Jr
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Explore the profile of G S Hughes Jr including associated specialties, affiliations and a list of published articles.
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28
Citations
90
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Recent Articles
1.
Hughes Jr G, Antal E, Locker P, Francom S, Adams W, Jacobs Jr E
Crit Care Med
. 1996 May;
24(5):756-64.
PMID: 8706450
Objective: To evaluate the physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier of bovine origin. Design: Randomized, single-blind, placebo-controlled, dose-escalation study. Setting: The Upjohn Research Clinics (Kalamazoo, MI). Subjects:...
2.
Hughes Jr G, Francome S, Antal E, Adams W, Locker P, Yancey E, et al.
J Lab Clin Med
. 1995 Nov;
126(5):444-51.
PMID: 7595029
The objective of this study was to assess the relationship between iron metabolism and pharmacokinetics of hemoglobin-based oxygen carrier-201 (HBOC-201), a polymerized hemoglobin product of bovine origin. A randomized, single-blind,...
3.
Hughes Jr G, Yancey E, Albrecht R, Locker P, Francom S, Orringer E, et al.
Clin Pharmacol Ther
. 1995 Oct;
58(4):434-43.
PMID: 7586936
Objective: The objective of this study was to evaluate the exercise capacity of subjects given an autologous transfusion or a polymerized bovine hemoglobin solution to define the pharmacodynamics and pharmacokinetics...
4.
Locker P, Jungbluth G, Francom S, Hughes Jr G
Clin Pharmacol Ther
. 1995 Jan;
57(1):73-88.
PMID: 7828385
Objective: To determine the effects of lifibrol on serum lipids in adult patients with primary hypercholesterolemia. Methods: These were two double-blind, randomized placebo-controlled studies. Each patient in each study had...
5.
Hughes Jr G, Ringer T, Francom S, Means L, DeLoof M
Am J Med Sci
. 1994 Jul;
308(1):16-22.
PMID: 8010332
Beta-carotene in doses of up to 300 mg daily raises high-density lipoprotein cholesterol levels within 2 to 4 weeks in healthy subjects. The authors, in this study, investigate the short-term...
6.
Hughes Jr G, DeSmith V, Locker P, Francom S
J Lab Clin Med
. 1994 Feb;
123(2):290-8.
PMID: 8301206
The purpose of this study was to evaluate the effects of phlebotomy of 500 or 750 ml of whole blood followed by isovolemic hemodilution or autologous transfusion on hemodynamic, hematologic,...
7.
Hanover C, Spillers C, Francom S, Locker P, Hughes Jr G
Methods Find Exp Clin Pharmacol
. 1992 Sep;
14(7):537-43.
PMID: 1287378
Repeated sampling for measurement of venous blood levels of hemoglobin, hematocrit, plasma hemoglobin, potassium and ibuprofen with a novel method of phlebotomy, the double stopcock technique (DST), was compared to...
8.
Hughes Jr G, Ringer T, Francom S, Caswell K, DeLoof M, Spillers C
Clin Pharmacol Ther
. 1991 Nov;
50(5 Pt 1):538-46.
PMID: 1934867
The effects of fish oil and naloxone on blood pressure, catecholamines, and endorphins during the cold pressor test were evaluated in a randomized, double-blind, placebo-controlled, two-way crossover trial of normotensive...
9.
Hughes Jr G, Heald D, Patel R, Spillers C, Batts D, Euler A
Methods Find Exp Clin Pharmacol
. 1990 Apr;
12(3):197-204.
PMID: 2352449
The effects of gastric motility on the pharmacokinetics of cefpodoxime proxetil, an oral, broad spectrum, third-generation cephalosporin antibiotic were evaluated in 12 healthy subjects. In this open-label, crossover trial, each...
10.
Hughes Jr G, VanderLugt J, Bays M, Bohan D, Francom S
Methods Find Exp Clin Pharmacol
. 1990 Mar;
12(2):155-60.
PMID: 2319840
Unlabelled: The effects of oral doses of metoclopramide (M, 10 mg) and propantheline (P, 30 mg) on alteration in gastric pH and emptying were determined using a continuous pH probe...