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G R Tintinger

Explore the profile of G R Tintinger including associated specialties, affiliations and a list of published articles. Areas
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Articles 18
Citations 161
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Recent Articles
1.
Joseph D, Theron A, Feldman C, Anderson R, Tintinger G
J Immunotoxicol . 2024 Apr; 21(1):2345152. PMID: 38659406
The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, , has focused attention on this microbial pathogen, which produces an array of virulence factors,...
2.
Pannell N, Joseph D, Ally M, Bida N, Tintinger G
Afr J Thorac Crit Care Med . 2021 Nov; 27(3). PMID: 34761206
Patients with rheumatoid arthritis (RA) may receive Janus kinase (JAK) inhibitors to achieve optimal control of their disease. We report a case of a patient who received a selective JAK1...
3.
Joseph D, Tintinger G, Ker J, Pannell N
Afr J Thorac Crit Care Med . 2021 Aug; 27(2). PMID: 34430870
The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function of T and...
4.
Taban E, Tintinger G, Joseph D, Gaylard P, Richards G
Afr J Thorac Crit Care Med . 2021 Aug; 27(2). PMID: 34430865
Background: COVID-19 caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) manifests with a range of disease severities. A small proportion of COVID-19 patients are severely ill; however, a...
5.
Nel J, Theron A, Durandt C, Tintinger G, Pool R, Mitchell T, et al.
Clin Exp Immunol . 2016 Jan; 184(3):358-67. PMID: 26749379
The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood...
6.
Theron A, Steel H, Tintinger G, Gravett C, Anderson R, Feldman C
J Immunol Res . 2014 Jun; 2014:608930. PMID: 24971371
Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory consequent to...
7.
Tintinger G, Anderson R, Feldman C
Semin Immunopathol . 2013 Mar; 35(4):395-409. PMID: 23494251
Although indispensable in host defense against microbial pathogens, misdirected hyperacute and chronic activation of neutrophils presents the potential hazard of tissue damage, organ dysfunction, and carcinogenesis. In many clinical settings,...
8.
Mokgobu M, Anderson R, Steel H, Cholo M, Tintinger G, Theron A
Inhal Toxicol . 2012 Aug; 24(10):634-44. PMID: 22906169
Although pro-inflammatory mechanisms have been implicated in the pathogenesis of manganese (Mn²⁺)-related neurological and respiratory disorders, relatively little is known about the potential of this metal to interact pro-oxidatively with...
9.
Kwofie L, Rapoport B, Fickl H, Meyer P, Rheeder P, Hlope H, et al.
Ann Hematol . 2011 Oct; 91(4):605-11. PMID: 21976106
The soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is a useful marker of infection in patients with sepsis, but has not been adequately evaluated in patients with chemotherapy-associated...
10.
Tintinger G, van der Merwe J, Fickl H, Rheeder P, Feldman C, Anderson R
Eur J Clin Microbiol Infect Dis . 2011 May; 31(1):73-6. PMID: 21559767
Soluble triggering receptor expressed on myeloid cells (s-TREM-1) is upregulated on the surface of inflammatory cells in the presence of bacterial infections, apparently excluding those due to Mycobacterium tuberculosis. Therefore,...