G R Thatcher
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Explore the profile of G R Thatcher including associated specialties, affiliations and a list of published articles.
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11
Citations
74
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Recent Articles
1.
Murray J, Macartney D, Thatcher G
Org Lett
. 2001 Nov;
3(23):3635-8.
PMID: 11700100
[reaction--see text] Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e(-) reduction....
2.
Artz J, TOADER V, Zavorin S, Bennett B, Thatcher G
Biochemistry
. 2001 Aug;
40(31):9256-64.
PMID: 11478893
Nitric oxide (NO) performs a central role in biological systems, binding to the heme site of soluble guanylyl cyclase (sGC), leading to enzyme activation and elevation of intracellular levels of...
3.
Toong S, Xiong Z, Zavorin S, Bai D, Orser B, Thatcher G, et al.
Can J Physiol Pharmacol
. 2001 Jun;
79(5):422-9.
PMID: 11405246
Positive modulators of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) channels reduce desensitization and alter their gating kinetics. We have discovered a novel compound nitric oxide-mimetic that similarly modulates the AMPA receptor by reducing...
4.
Lei S, Orser B, Thatcher G, Reynolds J, MacDonald J
J Neurophysiol
. 2001 May;
85(5):2030-8.
PMID: 11353019
Whole-cell or outside-out patch recordings were used to investigate the effects of protons and positive modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors on the desensitization of glutamate-evoked AMPA receptor currents in...
5.
Zavorin S, Artz J, Dumitrascu A, Nicolescu A, Scutaru D, Smith S, et al.
Org Lett
. 2001 May;
3(8):1113-6.
PMID: 11348172
[structure: see text]. The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to...
6.
Smith S, Dringenberg H, Bennett B, Thatcher G, Reynolds J
Neuroreport
. 2000 Dec;
11(17):3883-6.
PMID: 11117508
The objective of this study was to test the hypothesis that activation of soluble guanylyl cyclase and increased cGMP formation in the brain would improve task acquisition in cognitively impaired...
7.
Ferguson C, Thatcher G
Org Lett
. 2000 May;
1(6):829-32.
PMID: 10823212
[formula: see text] Aminocyclodextrins (ACDs), perfunctionalized at the 6-position with amino groups, bind phosphonoformate (PFA) diesters and accelerate acyl transfer reactions with high efficiency at neutral pH. Aminolysis and esterolysis...
8.
Ferguson C, Gorin B, Thatcher G
J Org Chem
. 2000 May;
65(4):1218-21.
PMID: 10814076
No abstract available.
9.
Artz J, Thatcher G
Chem Res Toxicol
. 1998 Dec;
11(12):1393-7.
PMID: 9860479
Unraveling the biology, pharmacology, and toxicology of NO depends on accurate NO assays, two of the more common being the oxyHb (oxyhemoglobin) assay and potentiometric detection using a Clark-type NO-selective...
10.
Vizitiu D, Kriste A, Campbell A, Thatcher G
J Mol Recognit
. 1996 Mar;
9(2):197-209.
PMID: 8877813
Enzyme inhibition studies on phosphatidylinositol-specific phospholipase C (PI-PLC) from B. Cereus were performed in order to gain an understanding of the mechanism of the PI-PLC family of enzymes and to...