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G R Strichartz

Explore the profile of G R Strichartz including associated specialties, affiliations and a list of published articles. Areas
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Articles 98
Citations 1796
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Recent Articles
1.
Makdessi M, Barr T, Xue W, Strichartz G
Acta Anaesthesiol Scand . 2015 Feb; 59(7):936-45. PMID: 25684033
Background: Endothelin-1 (ET-1) induces pain-like behavior in animals and man by activating the Gq protein-coupled receptor endothelin-A (ETA ). Activation of ETA receptors on nociceptor membranes evokes intracellular calcium transients...
2.
Wang G, Strichartz G
Biochem (Mosc) Suppl Ser A Membr Cell Biol . 2013 May; 6(2):120-127. PMID: 23710324
Knowledge about the mechanism of impulse blockade by local anesthetics has evolved over the past four decades, from the realization that Na channels were inhibited to affect the impulse blockade...
3.
Khodorova A, Strichartz G
Neuroscience . 2009 Oct; 165(2):553-60. PMID: 19874873
Subcutaneous injection of the peptide endothelin-1 (ET-1) into the rat's footpad is known to cause rapid, transient ipsilateral mechanical and thermal sensitization and nocifensive hind paw flinching. Here we report...
4.
Strichartz G
Br J Anaesth . 2008 May; 101(1):45-7. PMID: 18487246
This review considers the ion channels that underlie transduction of nociceptive energies in the periphery, that are involved in impulse initiation and propagation in peripheral sensory neurones, and that participate...
5.
Yanagidate F, Strichartz G
Handb Exp Pharmacol . 2006 Nov; (177):95-127. PMID: 17087121
Local anesthetics are used broadly to prevent or reverse acute pain and treat symptoms of chronic pain. This chapter, on the analgesic aspects of local anesthetics, reviews their broad actions...
6.
Gokin A, Philip B, Strichartz G
Anesthesiology . 2001 Dec; 95(6):1441-54. PMID: 11748404
Background: Controversy still surrounds the differential susceptibility of nerve fibers to local anesthetics and its relation to selective functional deficits. In the current study we report features of conduction blockade...
7.
Cogswell 3rd L, Raines D, Parekh S, JONAS O, Maggio J, Strichartz G
J Pharm Sci . 2001 Dec; 90(9):1407-23. PMID: 11745793
A novel probe was developed to measure drug association with the F1*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2-hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching...
8.
Gokin A, Fareed M, Pan H, Hans G, Strichartz G, Davar G
J Neurosci . 2001 Jul; 21(14):5358-66. PMID: 11438612
Neurobehavioral and neurophysiological actions of the peptide endothelin-1 (ET-1) were investigated after subcutaneous plantar hindpaw injections in adult male Sprague Dawley rats. Hindpaw flinching developed within minutes after ET-1 (8-16...
9.
Khodorova A, Meissner K, Leeson S, Strichartz G
Muscle Nerve . 2001 Apr; 24(5):634-47. PMID: 11317273
Abnormal, repetitive impulse firing arising from incomplete inactivation of Na+ channels may be involved in several diseases of muscle and nerve, including familial myotonias and neuropathic pain syndromes. Systemic local...
10.
Sinnott C, Garfield J, Thalhammer J, Strichartz G
Anesthesiology . 2000 Oct; 93(4):1045-52. PMID: 11020760
Background: Adding sodium bicarbonate to lidocaine to enhance its efficacy during peripheral nerve block is controversial. The authors studied the effect of adding sodium bicarbonate to lidocaine with and without...