G R GALE
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Explore the profile of G R GALE including associated specialties, affiliations and a list of published articles.
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Articles
165
Citations
431
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Recent Articles
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Jones M, Singh P, Basinger M, GALE G, Smith A, Harris W
Chem Res Toxicol
. 1994 May;
7(3):367-73.
PMID: 8075368
A novel method for the synthesis of monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) is presented which utilizes the reaction of the vicinal sulfhydryl-protected anhydride with the corresponding alcohol in the presence...
3.
Jones M, Basinger M, GALE G, Atkins L, Smith A, Stone A
Toxicology
. 1994 Apr;
89(2):91-100.
PMID: 8197593
The effects of chelating agent treatment with meso-2,3-dimercaptosuccinic acid (DMSA), Na2CaEDTA, Na2ZnEDTA, and Na3ZnDTPA on the organ lead levels of lead-loaded mice have been determined. At 1 mmol/kg/day i.p., all...
4.
Jones M, Singh P, Basinger M, GALE G, Smith A
Pharmacol Toxicol
. 1994 Feb;
74(2):76-83.
PMID: 8190706
Syntheses and relative cadmium mobilizing properties are described for three new monoaralkyl esters (HOOCCH(SH)CH(SH)COOR, where R = phenylethyl ((CH2)2C6H5), MPhEDMS; R = 3-phenylpropyl ((CH2)3C6H5), MPhPDMS; and R = 2-phenoxyethyl ((CH2)2OC6H5)....
5.
GALE G, Smith A, Jones M, Singh P
Toxicology
. 1993 Jul;
81(1):49-56.
PMID: 8396277
Seven monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were evaluated for relative activities in mobilizing and promoting excretion of mercury in mercury-laden mice. Compounds assessed were the ethyl (M-EDMS), n-propyl (Mn-PDMS), isopropyl...
6.
Walker Jr E, Stone A, Milligan L, GALE G, Atkins L, Smith A, et al.
Toxicology
. 1992 Dec;
76(1):79-87.
PMID: 1335621
The following six monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) were synthesized and evaluated for relative activities in mobilizing lead from kidneys and brains of lead-bearing mice: n-propyl (Mn-PDMS), i-propyl (Mi-PDMS),...
7.
GALE G, Smith A, Jones M, Singh P
Pharmacol Toxicol
. 1992 Dec;
71(6):452-6.
PMID: 1480554
A study was made of the effects of certain inhibitors of transport systems on the actions of four cadmium (Cd) complexing N,N-disubstituted dithiocarbamates (DTCs) in mobilizing murine renal and hepatic...
8.
Tasende M, GALE G, Smith A, Jones M, Singh P
Res Commun Chem Pathol Pharmacol
. 1992 Jun;
76(3):323-39.
PMID: 1636055
Monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) and the unesterified 2,3-dimercaptosuccinic acid (DMSA) were evaluated for relative reactivities against metallothionein (MT)-bound cadmium (Cd) in vitro by elution of the reaction products through Sephadex G-75...
9.
Jones M, Singh P, GALE G, Smith A, Atkins L
Pharmacol Toxicol
. 1992 May;
70(5 Pt 1):336-43.
PMID: 1319053
The relative activities of a series of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid have been examined as agents for the mobilization of cadmium from mice one week after intraperitoneal administration...
10.
Walker Jr E, Smith A, GALE G, Jones M
Res Commun Chem Pathol Pharmacol
. 1992 Jan;
75(1):121-4.
PMID: 1626122
Oral (po) administration of mono-iso-amyl (2,3-dimercapto) succinate (Mi-ADMS), 0.5 mmol/kg for three consecutive days, to mice previously injected with cadmium (Cd) chloride reduced the whole body Cd burden 34%. Intraperitoneal...