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G M Leclerc

Explore the profile of G M Leclerc including associated specialties, affiliations and a list of published articles. Areas
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Citations 103
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Recent Articles
1.
Leclerc G, Mou C, Leclerc G, Mian A, Barredo J
Leukemia . 2010 Jan; 24(3):552-62. PMID: 20072153
Children with acute lymphoblastic leukemia (ALL) diagnosed with resistant phenotypes, and those who relapse, have a dismal prognosis for cure. The antifolate methotrexate (MTX), a universal component of ALL therapies,...
2.
Gencic S, Leclerc G, Gorlatova N, Peariso K, Penner-Hahn J, Grahame D
Biochemistry . 2001 Oct; 40(43):13068-78. PMID: 11669645
Methyl group transfer reactions are essential in methane-forming pathways in all methanogens. The involvement of zinc in catalysis of methyl group transfer was studied for the methyltransferase enzyme MT2-A important...
3.
Leclerc G, Boockfor F, Faught W, Frawley L
Biotechniques . 2000 Sep; 29(3):590-1, 594-6, 598 passim. PMID: 10997273
Firefly luciferase is used widely as a reporter enzyme for studies of gene regulation and expression. The recent development of new technologies that combine luciferase reporter technology and digital imaging...
4.
Leclerc G, Grahame D
J Biol Chem . 1996 Aug; 271(31):18725-31. PMID: 8702528
A comparative study was made on the physicochemical characteristics of two isozymes of methylcobamide:- coenzyme M methyltransferase (MT2). Both isozymes catalyzed S-methylation of 2-thioethanesulfonate (coenzyme M) and exhibited similar apparent...
5.
Leclerc G, Diaz M, Ely B
Mol Mar Biol Biotechnol . 1996 Jun; 5(2):138-44. PMID: 8680526
We developed three assays that detect genetic variation at single-copy nuclear loci in striped bass (Morone saxatilis). Because these assays are based on restriction enzyme digests of DNA amplified by...