G M Groothuis
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Explore the profile of G M Groothuis including associated specialties, affiliations and a list of published articles.
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55
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525
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Recent Articles
1.
Olinga P, Meijer D, Slooff M, Groothuis G
Toxicol In Vitro
. 2010 Jul;
12(1):77-100.
PMID: 20654390
In the early years of research in in vitro pharmacotoxicology liver slices have been used. After a decline in the application of slices in favour of the use of isolated...
2.
Groothuis G, Sandker G, Pruim J, Weert B, Slooff M, Meijer D
Toxicol In Vitro
. 2010 Jul;
9(6):951-8.
PMID: 20650173
The aim of this study was to compare human hepatocytes isolated from livers accepted and from livers discarded for transplantation with respect to viability and drug transport function. In addition,...
3.
Verhoeven C, Gloudemans R, Peeters P, van Lier J, Verheggen F, Groothuis G, et al.
J Steroid Biochem Mol Biol
. 2001 Dec;
78(5):471-80.
PMID: 11738557
The metabolism of desogestrel (13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol), a progestagen used in oral contraceptives and hormone replacement therapy, was studied in vivo after a single oral administration of 150 microg [14C]-labeled desogestrel and...
4.
Beljaars L, Olinga P, Molema G, De Bleser P, Geerts A, Groothuis G, et al.
Liver
. 2001 Oct;
21(5):320-8.
PMID: 11589768
Background/aims: Drug targeting to hepatic stellate cells (HSC) may improve the pharmacological effects of antifibrotic drugs. Recently, albumin substituted with 28 mannose 6-phosphate moieties (M6P(28)-HSA) was found to distribute selectively...
5.
Melgert B, Olinga P, Van Der Laan J, Weert B, Cho J, Schuppan D, et al.
Hepatology
. 2001 Oct;
34(4 Pt 1):719-28.
PMID: 11584368
Kupffer cells (KC) play an important role in the pathogenesis of inflammatory liver diseases leading to fibrosis. Anti-inflammatory drugs are only effective when administered at high doses that may cause...
6.
Olinga P, Merema M, de Jager M, Derks F, Melgert B, Moshage H, et al.
J Hepatol
. 2001 Oct;
35(2):187-94.
PMID: 11580140
Background/aims: Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. Methods: We...
7.
Olinga P, Hof I, Merema M, Smit M, de Jager M, Swart P, et al.
J Pharmacol Toxicol Methods
. 2001 Aug;
45(1):55-63.
PMID: 11489665
In the present study we investigated the applicability of the liver slice model to study mechanisms of drug uptake. Four model compounds were investigated that enter hepatocytes via entirely different...
8.
van Montfoort J, Muller M, Groothuis G, Meijer D, Koepsell H, Meier P
J Pharmacol Exp Ther
. 2001 Jun;
298(1):110-5.
PMID: 11408531
Previous inhibition studies with taurocholate and cardiac glycosides suggested the presence of separate uptake systems for small "type I" (system1) and for bulky "type II" (system2) organic cations in rat...
9.
Melgert B, Olinga P, Weert B, Slooff M, Meijer D, Poelstra K, et al.
Drug Metab Dispos
. 2001 May;
29(6):361-7.
PMID: 11353741
We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis...
10.
Melgert B, Olinga P, Weert B, Slooff M, Meijer D, Poelstra K, et al.
Drug Metab Dispos
. 2001 Mar;
29(4 Pt 1):361-7.
PMID: 11259317
We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis...