G M Gauvreau
Overview
Explore the profile of G M Gauvreau including associated specialties, affiliations and a list of published articles.
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39
Citations
654
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Recent Articles
1.
Gauvreau G, Fitzgerald J, Boulet L, Watson R, Hui L, Villineuve H, et al.
Clin Exp Allergy
. 2018 Feb;
48(4):445-451.
PMID: 29423947
Background: CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. Objective: This proof-of-mechanism...
2.
Revez J, Killian K, OByrne P, Boulet L, Upham J, Gauvreau G, et al.
Allergy
. 2018 Jan;
73(7):1470-1478.
PMID: 29337345
Background: In mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. We investigated whether this observation extends to humans. Methods: We compared...
3.
MITCHELL P, Salter B, Oliveria J, El-Gammal A, Tworek D, Smith S, et al.
Clin Exp Allergy
. 2016 Dec;
47(3):331-338.
PMID: 27928844
Background: Glucagon-like peptide-1 (GLP-1) and its receptor are part of the incretin family of hormones that regulate glucose metabolism. GLP-1 also has immune modulatory roles. Objectives: To measure the expression...
4.
Gauvreau G, Boulet L, Fitzgerald J, Cockcroft D, Davis B, Leigh R, et al.
Allergy
. 2016 Jul;
71(12):1721-1727.
PMID: 27444660
Background: The cysteinyl leukotrienes (cysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as potent bronchoconstrictors, cysLTs contribute to airway inflammation through eosinophil and neutrophil...
5.
Baatjes A, Smith S, Dua B, Watson R, Gauvreau G, OByrne P
Allergy
. 2015 Jul;
70(11):1505-8.
PMID: 26213896
OX40-OX40L interactions and thymic stromal lymphopoietin (TSLP) are important in the induction and maintenance of Th2 responses in allergic disease, whereas T regulatory cells (Treg) have been shown to suppress...
6.
Gauvreau G, Boulet L, Cockcroft D, Fitzgerald J, Mayers I, Carlsten C, et al.
Clin Exp Allergy
. 2013 Nov;
44(1):29-37.
PMID: 24224471
Background: The OX40/OX40L interaction contributes to an optimal T cell response following allergic stimuli and plays an important role in the maintenance and reactivation of memory T effector cells. Objective:...
7.
8.
OByrne P, Naji N, Gauvreau G
Clin Exp Allergy
. 2012 Apr;
42(5):706-11.
PMID: 22515391
Background: Patients with severe refractory asthma have not achieved asthma control, even with high doses of ICS, usually in combination with LABAs and other maintenance treatments. Objective: The most promising...
9.
Imaoka H, Gauvreau G, Watson R, Smith S, Dua B, Baatjes A, et al.
Eur Respir J
. 2011 Oct;
38(4):981-3.
PMID: 21965503
No abstract available.
10.
Imaoka H, Campbell H, Babirad I, Watson R, Mistry M, Sehmi R, et al.
Clin Exp Allergy
. 2011 Jul;
41(12):1740-6.
PMID: 21762225
Background: TPI ASM8 contains two modified phosphorothioate antisense oligonucleotides (AON), one targeting the common beta chain (βc) of the IL-3/IL-5/GM-CSF receptors and the other targeting the chemokine receptor CCR3. Inhalation...