G M Doody
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Explore the profile of G M Doody including associated specialties, affiliations and a list of published articles.
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11
Citations
363
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Recent Articles
1.
Xie X, van Delft M, Shuweihdi F, Kingsbury S, Trouw L, Doody G, et al.
Osteoarthritis Cartilage
. 2021 Mar;
29(6):924-933.
PMID: 33757859
Objective: Autoantibodies (AutoAbs) have been observed in osteoarthritis (OA) with broad antigenicity, although their prevalence and role remain unclear. Post-translational modification (PTMs) of proteins (oxidation, carbamylation, citrullination) is associated with...
2.
Doody G, Leek J, Bali A, Ensser A, Markham A, de Wynter E
Gene Ther
. 2004 Dec;
12(4):373-9.
PMID: 15616605
Herpesvirus-based gene therapy vectors offer an attractive alternative to retroviral vectors because of their episomal nature and ability to accommodate large transgenes. Saimiriine herpesvirus 2 (HVS) is a prototypical gamma-2...
3.
Doody G, Bell S, Vigorito E, Clayton E, McAdam S, Tooze R, et al.
Nat Immunol
. 2001 May;
2(6):542-7.
PMID: 11376342
B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response...
4.
Doody G, Billadeau D, Clayton E, Hutchings A, Berland R, McAdam S, et al.
EMBO J
. 2000 Nov;
19(22):6173-84.
PMID: 11080163
We show here that Vav-2 is tyrosine phosphorylated following antigen receptor engagement in both B- and T-cells, but potentiates nuclear factor of activated T cells (NFAT)-dependent transcription only in B...
5.
Smith K, Tarlinton D, Doody G, Hibbs M, Fearon D
J Exp Med
. 1998 Mar;
187(5):807-11.
PMID: 9480991
Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22...
6.
Tooze R, Doody G, Fearon D
Immunity
. 1997 Jul;
7(1):59-67.
PMID: 9252120
The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple...
7.
8.
Carter R, Doody G, Bolen J, Fearon D
J Immunol
. 1997 Apr;
158(7):3062-9.
PMID: 9120258
CD19 enhances membrane IgM (mIgM) signaling and is required for B lymphocyte responses to T-dependent Ags. CD19 is tyrosine phosphorylated when mIgM is ligated and binds SH2 domain-containing signaling proteins....
9.
Doody G, Dempsey P, Fearon D
Curr Opin Immunol
. 1996 Jun;
8(3):378-82.
PMID: 8793993
Three accessory membrane proteins, CD19, CD22 and Fc gamma RIIb1, alter signaling through membrane immunoglobulin of B cells by binding cytosolic proteins containing SH2 domains. Recent biochemical and genetic studies...
10.
Doody G, Justement L, Delibrias C, Matthews R, Lin J, Thomas M, et al.
Science
. 1995 Jul;
269(5221):242-4.
PMID: 7618087
CD22 is a membrane immunoglobulin (mIg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mIg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively...