G J Strous
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Explore the profile of G J Strous including associated specialties, affiliations and a list of published articles.
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115
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2954
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Recent Articles
1.
Strous G, Bloemendal H
Mol Biol Rep
. 2013 Nov;
1(2):99-104.
PMID: 24197473
The optimal magnesium ion concentration for chain initiation in a cell-free system derived from bovine eye lens which synthesizes 4 classes of crystallins appears to be 5 mM. In the...
2.
Strous G, dos Santos C, Gent J, Govers R, Sachse M, Schantl J, et al.
Curr Top Microbiol Immunol
. 2005 Jan;
286:81-118.
PMID: 15645711
The growth hormone (GH) receptor is a key regulator of cellular metabolism. Unlike most growth factor receptors, its downregulation is not initiated by its ligand. Like many growth factor receptors,...
3.
4.
Strous G, Schantl J
Sci STKE
. 2001 Nov;
2001(110):pe41.
PMID: 11724970
Mdm2 is a ubiquitin-protein ligase known to ubiquitinate p53, promoting its degradation by the ubiquitin-proteasome system. Shenoy and co-workers showed that Mdm2 can act as a key factor in the...
5.
Sachse M, van Kerkhof P, Strous G, Klumperman J
J Cell Sci
. 2001 Nov;
114(Pt 21):3943-52.
PMID: 11719561
Endocytosis of the growth hormone receptor (GHR) requires an active ubiquitin-conjugation system. In addition, it depends on a 10 amino acid residues motif in the GHR-cytoplasmic tail, the ubiquitin dependent-endocytosis...
6.
van Kerkhof P, Alves dos Santos C, Sachse M, Klumperman J, Bu G, Strous G
Mol Biol Cell
. 2001 Aug;
12(8):2556-66.
PMID: 11514635
The ubiquitin-proteasome pathway acts as a regulator of the endocytosis of selected membrane proteins. Recent evidence suggests that it may also function in the intracellular trafficking of membrane proteins. In...
7.
van Kerkhof P, Strous G
Biochem Soc Trans
. 2001 Aug;
29(Pt 4):488-93.
PMID: 11498015
The growth hormone (GH) receptor (GHR) is a mammalian plasma membrane protein whose internalization is mediated by the ubiquitin-proteasome pathway. GH internalization and degradation are inhibited when cells are treated...
8.
Alves dos Santos C, ten Broeke T, Strous G
J Biol Chem
. 2001 Jun;
276(35):32635-41.
PMID: 11418602
The ubiquitin-proteasome system is required in growth hormone receptor (GHR) endocytosis. For cytokine receptors, which lack intrinsic tyrosine kinase activity, signal transduction is initiated by the activation of a member...
9.
Li Y, van Kerkhof P, Marzolo M, Strous G, Bu G
Mol Cell Biol
. 2001 Feb;
21(4):1185-95.
PMID: 11158305
The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multiligand endocytic receptor that belongs to the LDL receptor family. Recently, studies have revealed new roles of LDL receptor family members...
10.
Alves dos Santos C, van Kerkhof P, Strous G
J Biol Chem
. 2001 Jan;
276(14):10839-46.
PMID: 11152671
The growth hormone receptor (GHR) intracellular domain contains all of the information required for signal transduction as well as for endocytosis. Previously, we showed that the proteasome mediates the clathrin-mediated...