G F Vile
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Explore the profile of G F Vile including associated specialties, affiliations and a list of published articles.
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21
Citations
372
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Recent Articles
1.
Vile G, Rothwell L, Kettle A
Arch Biochem Biophys
. 2000 Apr;
377(1):122-8.
PMID: 10775450
Oxidants produced by neutrophils have been implicated in causing cancers associated with chronic inflammation. Hypochlorous acid is the most potent oxidant produced by these cells in appreciable amounts. It reacts...
2.
Vile G, Rothwell L, Kettle A
Arch Biochem Biophys
. 1998 Nov;
359(1):51-6.
PMID: 9799559
The carcinogenicity associated with chronic inflammation has been attributed to neutrophils and the oxidants they produce. Neutrophils accumulate at sites of chronic inflammation, where they are stimulated to produce hydrogen...
3.
Vile G
FEBS Lett
. 1997 Jul;
412(1):70-4.
PMID: 9257692
Active oxygen species mediate many of the biological consequences of exposing cultured human skin cells to solar ultraviolet (UV) radiation (290-380 nm). A critical step in the escape from the...
4.
Applegate L, Scaletta C, Labidi F, Vile G, Frenk E
Int J Cancer
. 1996 Jul;
67(3):430-4.
PMID: 8707420
Ultraviolet radiation, and in particular UVA (320-400 nm), induces significant oxidative stress to human skin. Ferritin and glutathione have been shown to be among the more important molecules within human...
5.
Vile G, Tyrrell R
Photochem Photobiol
. 1995 Sep;
62(3):463-8.
PMID: 8570706
We have examined the role of the nucleus and the membrane in the activation of nuclear factor (NF)-kappa B by oxidant stress generated via the UVA (320-380 nm) component of...
6.
Vile G, Tyrrell R
Free Radic Biol Med
. 1995 Apr;
18(4):721-30.
PMID: 7750796
This study describes the damage that occurs to lipids and proteins that have been irradiated in vitro or in human skin fibroblasts with physiological doses of UVA radiation. Thiobarbituric acid-reactive...
7.
Vile G, WALTNER C, Tyrrell R
Proc Natl Acad Sci U S A
. 1994 Mar;
91(7):2607-10.
PMID: 8146161
Oxidative stress of human skin fibroblasts by treatment with ultraviolet A (UVA) radiation has been shown to lead to an increase in levels of the heme catabolizing enzyme heme oxygenase...
8.
Vile G, Tyrrell R
J Biol Chem
. 1993 Jul;
268(20):14678-81.
PMID: 8325845
Heme oxygenase-1 mRNA levels increase following exposure of many mammalian cell lines to oxidative stress such as ultraviolet A (UVA) irradiation. Here we demonstrate a 4-fold increase in microsomal heme...
9.
Thomas C, Vile G, Winterbourn C
Biochem Pharmacol
. 1993 May;
45(10):1967-72.
PMID: 8390256
d-1,2-Bis(3,5-dioxopiperazine-1-yl)propane (ICRF-187) (ADR-529) is a drug that ameliorates the cardiotoxicity of Adriamycin. The drug enters cells where hydrolysis leads to its diacid diamide product, dl-N,N'-dicarboxamidomethyl-N,N'-dicarboxymethyl-1,2-diamino propane (ICRF-198) (ADR-925), which is...
10.
Winterbourn C, Vile G, Monteiro H
Free Radic Res Commun
. 1991 Jan;
12-13 Pt 1:107-14.
PMID: 1649077
A number of xenobiotics are toxic because they redox cycle and generate free radicals. Interaction with iron, either to produce reactive species such as the hydroxyl radical, or to promote...