G Cooper 4th
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Explore the profile of G Cooper 4th including associated specialties, affiliations and a list of published articles.
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84
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Recent Articles
1.
Cooper 4th G
Heart Fail Rev
. 2005 Oct;
5(3):187-201.
PMID: 16228904
The Frank-Starling mechanism, by which load directly regulates muscle length and thus performance is the means by which the mechanics and energetics of cardiac muscle are regulated on a beat-to-beat...
2.
Zile M, Green G, Schuyler G, Aurigemma G, Miller D, Cooper 4th G
J Am Coll Cardiol
. 2001 Mar;
37(4):1080-4.
PMID: 11263612
Objectives: We sought to determine whether the cardiocyte microtubule network densification characteristic of animal models of severe pressure overload cardiac hypertrophy occurs in human patients. Background: In animal models of...
3.
Pereira N, Cooper 4th G
Clin Cornerstone
. 2001 Feb;
3(2):1-12.
PMID: 11212858
Congestive heart failure (CHF) is being described as an epidemic of the next decade. Despite significant advances in the treatment of systolic heart failure, community mortality remains high, which is...
4.
Ishibashi Y, Rembert J, Carabello B, Nemoto S, Hamawaki M, Zile M, et al.
Am J Physiol Heart Circ Physiol
. 2000 Dec;
280(1):H11-6.
PMID: 11123212
Severe left ventricular volume overloading causes myocardial and cellular contractile dysfunction. Whether this is also true for severe right ventricular volume overloading was unknown. We therefore created severe tricuspid regurgitation...
5.
Laser M, Willey C, Jiang W, Cooper 4th G, Menick D, Zile M, et al.
J Biol Chem
. 2000 Aug;
275(45):35624-30.
PMID: 10958798
Cardiac hypertrophy is characterized by both remodeling of the extracellular matrix (ECM) and hypertrophic growth of the cardiocytes. Here we show increased expression and cytoskeletal association of the ECM proteins...
6.
Nagai T, Laser M, Baicu C, Zile M, Cooper 4th G, Kuppuswamy D
Am J Cardiol
. 2000 Apr;
83(12A):38H-43H.
PMID: 10750585
In vivo studies show that beta3-integrin-mediated focal adhesion formation (FAF) causes recruitment of nonreceptor tyrosine kinases to the cytoskeleton in pressure-overloaded myocardium. To define the mechanism of beta3-integrin-mediated signaling, we...
7.
Nagatsu M, Spinale F, Koide M, Tagawa H, Defreitas G, Cooper 4th G, et al.
Circulation
. 2000 Feb;
101(6):653-9.
PMID: 10673258
Background: It is clear that beta-blockers are effective for treatment of congestive heart failure, but their mechanism of action remains controversial. Hypothesized mechanisms include normalization of beta-receptor function and myocardial...
8.
Narishige T, Blade K, Ishibashi Y, Nagai T, Hamawaki M, Menick D, et al.
J Biol Chem
. 1999 Mar;
274(14):9692-7.
PMID: 10092657
Increased microtubule density, through viscous loading of active myofilaments, causes contractile dysfunction of hypertrophied and failing pressure-overloaded myocardium, which is normalized by microtubule depolymerization. We have found this to be...
9.
Koide M, Carabello B, Conrad C, Buckley J, DeFreyte G, Barnes M, et al.
Am J Physiol
. 1999 Feb;
276(2 Pt 2):H350-8.
PMID: 9950833
Myocardial hypertrophy is one of the basic mechanisms by which the heart compensates for hemodynamic overload. The mechanisms by which hemodynamic overload is transduced by the cardiac muscle cell and...
10.
Zile M, Koide M, Sato H, Ishiguro Y, Conrad C, Buckley J, et al.
J Am Coll Cardiol
. 1999 Feb;
33(1):250-60.
PMID: 9935038
Objectives: We sought to determine whether the ameliorative effects of microtubule depolymerization on cellular contractile dysfunction in pressure overload cardiac hypertrophy apply at the tissue level. Background: A selective and...